Creative Biolabs is an undisputed leading provider of antibody development and generation services. Now, we provide in vitro diagnostic (IVD) antibody development services targeting various biomarkers of a wide variety of diseases. Especially, Creative Biolabs offers high-quality antibody development services for diagnostic applications targeting CCR3 as a potential marker of sepsis.
C-C Chemokine Receptor Type 3 (CCR3)
C-C chemokine receptor type 3 (CCR3), also designated cluster of differentiation 193 (CD193), is a protein that encoded by the CCR3 gene in humans. The protein is a receptor for C-C type chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and also detected in Th1 and Th2 cells, as well as in airway epithelial cells. In humans, Th1 cells mainly secrete IFN-γ and promote cell-mediated immune response and macrophage activation. Th2 cells produce IL-4, IL-5, and IL-13 and promote humoral immunity. It is known that CCR3 may be associated with the activation and accumulation of eosinophils and other inflammatory cells in the allergic airway. Besides, it may exist on sites of parasitic infection involving the regulation of inflammatory response.
Fig.1 Recruitment of innate immune cells to the site of infection in the liver. (Brass A., 2014)
The Role of CCR3 in Sepsis
Sepsis is a serious infection that causes your immune system to attack your body. It occurs when the body's response to infection causes injury to its own tissues and organs. It is reported that the shift of T lymphocytes toward a Th2 profile can be established during septic shock on the condition of in vitro cytokine production. Moreover, eotaxin as the ligand of CCR3 is a pivotal chemokine clearly involved in Th2/allergic processes and the Th2 cells promote humoral immunity. Beside, CCR3 and cytokine can activate inflammatory cells and promote their migration into the sites of inflammatory response, thereby regulating inflammatory allergic response. Some studies implicated that the expression of CCR3 or CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells) is decreased in the septic shock patients. Thus CCR3 may be a candidate for sepsis monitoring. However, whether relevance exists between the CCR3 levels and the indicators of infectious deceases, such as sepsis, is still required a lot of experimental data to verify.
IVD Antibody Development Services Targeting CCR3 Marker
IVD antibodies have been commonly used in immunodiagnostic kits for the disease diagnosis and prognosis. Creative Biolabs has built a versatile IVD platform to provide custom biomarker-specific IVD antibody development services to global clients. Along with over a decade of rich experience in providing excellent custom services for IVD antibody discovery, our services can totally meet your special requirements.
In addition, Creative Biolabs provides one-stop diagnostic immunoassay development services, including feasibility analysis, assay design, assay protocol establishment, validation, and production. If you are interested in our services, please do not hesitate to contact us for more details.
Reference
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