As a world-leading service provider of antibody development and generation, Creative Biolabs is ready to provide a whole series of biomarker-specific in vitro diagnostic (IVD) antibody development services. A team of experienced scientists focused on antibody development are pleased to assist you in your project in a timely and cost-effective manner. Here, we introduce our IVD antibody development services targeting CD81 marker.

CD81 Antigen (CD81)

CD18 molecule encodes the protein which is a member of the transmembrane 4 superfamily, also called the tetraspanin family. Most proteins in this family are cell-surface proteins that are characterized by the presence of four hydrophobic domains. As one member of the family, CD81 plays a role in the regulation of cell development, activation, growth, and motility though mediating signal transduction. CD81 is located in the tumor-suppressor gene region. That is why this gene can be a candidate for malignancies. Moreover, CD18 acts as a receptor for hepatitis C virus (HCV) in hepatocytes.

Involvement of CD81 in Hepatitis C Virus (HCV) lifecycle. Fig.1 Involvement of CD81 in Hepatitis C Virus (HCV) lifecycle. (Lucie Fénéant., 2014)

CD81 Marker of Hepatitis

Hepatitis C virus (HCV) is an enveloped, positive-stranded RNA virus classified in the family Flaviviridae. An estimated hundreds millions of individuals worldwide are infected with HCV. Infection is associated with the development of chronic hepatitis, cirrhosis, and hepatocellular carcinoma. The principal site of virus replication is thought to be the liver. HCV encodes two putative envelope gp's, E1 and E2, which are believed to be type I integral transmembrane proteins. the mechanism(s) by which HCV enters target cells is currently unknown. In the absence of a cell culture system, surrogate assays have been developed to study HCV entry, including the expression of a truncated version(s) of the E2 gp, E1, E2-liposomes, vesicular stomatitis virus (VSV)-HCV pseudotypes, and virus like particles expressed in insect cell systems HCV encodes two putative envelope gp's, E1 and E2, which are believed to be type I integral transmembrane proteins. Human CD81 was identified to interact with soluble HCV E2 and virus in serum and was proposed to play a role in HCV entry.

Schematic representation of the tetraspanin CD81. Fig.2 Schematic representation of the tetraspanin CD81. (Lucie Fénéant, 2014)

IVD Antibody Development Services Targeting CD81 Marker

IVD antibodies have been widely used for disease screening and therapeutic monitoring. As a research partner with years of experience in high-quality antibody development and production, Creative Biolabs offers one-stop solutions from antigen design to antibody pair screening. Besides, we also offer diagnostic immunoassay development services, including feasibility analysis, assay design, assay protocol establishment, assay optimization, and kit production.

Our services can be tailor-designed to adapt to specific project specifications. If you are interested in our services, please do not hesitate to contact us for more details.

Reference

  1. Lucie Fénéant., (2014) “CD81 and Hepatitis C Virus (HCV) Infection.” Viruses, 6 (2): 535-572.


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