As a leading CRO of antibody generation and development, Creative Biolabs offers application-specific antibody development services to global clients. With experienced scientists and advanced technology, we have established a series of high-quality in vitro diagnostic (IVD) antibody development services against biomarkers of different diseases. Here, we introduce our IVD antibody development services for cholinesterase (ChE).

Introduction of Cholinesterase (ChE) Marker

Cholinesterase (ChE) is a member of the cholinesterases family which is found in nerve endings as well as in erythrocytes and other tissues. There are two types of cholinesterase: acetylcholinesterase (ACHE) and butyrylcholinesterase (BCHE) with the former hydrolyzes acetylcholine more quickly and the latter hydrolyzes butyrylcholine more quickly. The term cholinesterase is usually used to refer specifically to butyrylcholinesterase which is synthesized in the liver and thus can be an accurate reflection of liver function. In addition, serum cholinesterase is closely associated with the synthesis of serum albumin and has many diagnostic applications. Importantly, the level of cholinesterase may be reduced in patients with the advanced liver disease.

Two cholinesterases contribute to the cholinergic status Fig.1 Two cholinesterases contribute to the cholinergic status (Arbel Y., 2014)

Cholinesterase (ChE) Marker of Liver Cirrhosis

In the past years, studies have suggested that the level of serum ChE is able to reflect liver function adequacy in various clinical situations. For example, in familial intrahepatic cholestasis, following successful external biliary diversion, increasing levels of serum ChE have been shown to be a marker of successful surgery. As a unique enemy that is exclusively synthesized by the liver like albumin and coagulation factors, serum ChE level of patients with cirrhosis is significantly lower than that of healthy people. What’s more, it has also been reported that patients with decompensated cirrhosis had significantly lower levels of serum ChE compared to well-compensated cirrhosis. In this case, cholinesterase can be used as an excellent biomarker of cirrhosis with good sensitivity and specificity.

IVD Antibody Development Services for ChE Marker

IVD antibodies have been widely used in immunodiagnostic tools to aid in the diagnosis of various diseases, conditions, and infections. With years of experience and advanced technology, Creative Biolabs is able to provide a full range of high-quality and cost-effective biomarker-specific antibody development services. Especially, we help develop novel anti-ChE antibodies for your IVD projects.

Having completed a number of IVD antibody generation and development projects, Creative Biolabs is confident to offer you the best products and services to promote your project a success. For more details and information, please feel free to contact us and get a quote.

Reference

  1. Arbel Y., (2014) “Decline in serum cholinesterase activities predicts 2-year major adverse cardiac events.” Molecular medicine, 20(1): 38.


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