Creative Biolabs is a world-leading service provider for in vitro diagnostic (IVD) antibody discovery and development. Based on our extensive experience and advanced technology platforms, we provide IVD antibody development services targeting a broad range of disease biomarkers. Here, we introduce our IVD antibody development services targeting the chorionic gonadotropin, a potential marker for the diagnosis of testicular cancer.

Human Chorionic Gonadotropin (hCG)

Human chorionic gonadotropin (hCG) is one type of glycoprotein composed of 237 amino acids with the molecular weight of 36.7 kDa. As a member of glycoprotein hormone family, hCG is heterodimer consisting of an α and β subunit. The hCGα contains 92 amino acids with a molecular weight of 14.5 kDa while hCGβ contains 145 amino acids with a molecular weight of 22.2 kDa. In general, the hCG can be produced by placental trophoblasts with a very high concentration. Some studies have shown that the hCG can be served as the sensitive marker as it can be expressed in placental and other trophoblastic. Moreover, the increased level of hCGβ can also be detected in many nontrophoblastic tumors. In addition, the low levels of hCG and hCGβ can be detected via sensitive and specific assays in many tissues of most men and nonpregnant women. In recent years, it has been reported that the hCG plays an important role in testicular cancer and has a great potential for its diagnosis.

IVD Antibody Development Services for Chorionic Gonadotropin Marker Fig.1 The structure of human chorionic gonadotropin.

The Functions of HCG

  • Interacts with the LHCG receptor of the ovary and promotes the maintenance of the corpus luteum during the beginning of pregnancy.
  • Prenatal protection of the fetus in early pregnancy via repelling the immune cells from mother.
  • Induction of the ovulation and testosterone production in the testis.
  • Plays a role in cell proliferation and differentiation.

IVD Antibody Development Services for Chorionic Gonadotropin Marker Fig.2 The diagram of testicular cancer.

Chorionic Gonadotropin Marker of Testicular Cancer

Testicular cancer is cancer that develops from the testicle which is a part of the reproductive system in the male. As common cancer in men age 20-35 years, the cure rate of the low-stage disease can reach to 95%. With the symptoms of testicular mass, scrotum swelling and pain, the treatment of testicular cancer always results in infertility. Moreover, the relapses are fairly common without the adjuvant therapy, and the patients need to be monitored carefully for many years. In this case, it is necessary and urgent to find a marker for the diagnosis. In general, the normal range of HCG is between 0-5 MIU/mL for man. In testicular cancer, both hCG and hCGβ can be increased and lots of assays show that compared with hCG, hCGβ is a better diagnostic marker for testicular cancer.

With our versatile IVD platform, Creative Biolabs is proud to develop novel hCG-specific antibodies from scratch to commercial IVD kit (we can also start with provided antibody candidates). With over a decade of rich experience for the IVD antibody discovery, now Creative Biolabs is able to design specific study protocols to suit our customers' special requirements. If you are interested in our service, please do not hesitate to contact us for more details.

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