With abundant experience in in vitro diagnostic (IVD) antibody development, Creative Biolabs has become an unparalleled company to provide a great variety of IVD antibody development services for different disease biomarkers. Here, we introduce coronin-1A as a potential marker for bladder cancer diagnosis. Our professional scientists are confident in offering high-quality antibodies for our global clients to help improve the diagnosis of bladder cancer.
Introduction of Coronin-1A
Coronins are highly conserved actin-binding proteins that regulate various cellular processes, such as cell motility and phagosome formation. Human coronin-1A (CORO1A), a member of the coronin families, is a crucial component of the actin cytoskeleton and promotes cellular processes including endocytosis and cell motility. It comprises an aminoterminal tryptophan-aspartate (WD) repeat-containing region, a unique region (U) of variable length, and a carboxy-terminal coiled-coil domain (CC) required for oligomerization. In addition, coronin-1A is widely expressed in brain, thymus, spleen, bone marrow, and lymph nodes, and selective cytoplasmic expression has been reported in leukocytes and microglia.
Fig.1 A coronin 1A-based multi-protein complex mediates a positive feedback loop that contributes to sustained Rac1 activation. (Symons M, 2011)
Coronin-1A Marker of Bladder Cancer
Coronin-1A is highly expressed in the hematopoietic system and regulates F-actin content in thymocytes. It has been reported that coronin-1A is significantly correlated with the development and migration of breast cancer cells when compared with normal cell lines. Besides, coronin-1A has been identified as a novel antibody target for the clinically isolated syndrome and multiple sclerosis. Moreover, gene expression studies have shown that the expression of coronin-1A in lymphomas and other hematological malignancies is altered. Most importantly, studies have shown that the level of coronin-1A is significantly upregulated in Ta/T1 and T2/T3 urine samples relative to that in samples from healthy subjects, which makes it a potential biomarker for the diagnostics of bladder cancer.
IVD Antibody Development Services Targeting Coronin-1A Marker
With the rapid development of IVD technology, IVD antibodies, and antibody-based immunodiagnostics have been widely developed and used for the diagnosis of many kinds of diseases. As a well-recognized expert in the field of antibody development for many years, Creative Biolabs proudly introduces our versatile IVD platform to offer novel IVD antibody (pairs) to global clients. Moreover, we can offer immunoassay development, IVD kit development, and manufacturing services from scratch or using provided antibodies.
Creative Biolabs has completed a lot of programs for our worldwide customers based on our abundant experience and advanced technologies. We are confident in offering the most cost-effective IVD antibody development services for coronin-1A marker to our customers. Besides coronin-1A marker, Creative Biolabs also focuses on other potential biomarkers. If you are interested in our service, please do not hesitate to contact us for more details and get a quote. We will work closely with you to meet every customer's requirements.
Reference
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