Creative Biolabs is a contract research organization specialized in offering customized services for the development of antibodies for use in diagnostics, drug discovery, and basic research. Especially, we provide the expertise and personnel to offer high-quality in vitro diagnostic (IVD) antibody development services targeting a wide range of high-value diagnostic biomarkers to our clients. Here, we introduce our IVD antibody development services for Cx3Cr1 marker.

Introduction of Cx3Cr1 Marker

CX3C chemokine receptor 1 (CX3CR1), also known as the fractalkine receptor or G-protein coupled receptor 13 (GPR13), is a protein that encoded by the human CX3CR1 gene. As the name suggests, this receptor binds the fractalkine ligand CX3CL1 which is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. It has been reported that the expression of CX3CR1 is associated with lymphocytes. In addition, CX3CR1 is also expressed by monocytes and plays a vital role in the survival of monocytes. Recently, studies have discovered that CX3CR1 plays a developmental role in the migration of microglia in the central nervous system to their synaptic targets, where phagocytosis and synaptic refinement occur. What’s more, CX3CR1 knockout mice had more synapses on cortical neurons when compared with wild-type mice.

CX3CL1/CX3CR1 signaling in liver inflammation Fig.1 CX3CL1/CX3CR1 signaling in liver inflammation (Lee M., 2018)

Cx3Cr1 Marker of Fibrosis

Liver fibrosis is the hallmark of all chronic liver diseases and is associated with high mortality and morbidity. It has been reported that the genetic basis of liver fibrosis is complex and that multiple genes are involved in the distinct pathobiological processes of fibrogenesis. As a highly selective chemokine receptor and surface marker for NK cells, T lymphocytes and cd T cells, as well as monocytes, CX3CR1 is expressed in chronic HCV infection and constitute important chemoattractants for the recruitment of lymphocytes to the inflamed liver. Most importantly, studies have suggested that functionally relevant coding variants of CX3CR1 are associated with the stage of liver fibrosis. In addition, serum levels of fractalkine, the specific ligand for CX3CR1, are significantly higher in patients with HCV and other chronic liver diseases that can result in liver fibrosis. Under this case, Cx3Cr1 can be used as a potential marker for the determination of liver fibrosis.

IVD Antibody Development Services Targeting Cx3Cr1 Marker

Aided by our advanced IVD platform, Creative Biolabs is able to generate antibodies with high affinity and specificity that are specific to diagnostic targets, such as Cx3Cr1 marker. Besides, we also provide services to biotech companies and academic researchers for their needs in developing diagnostic immunoassays of various formats, including lateral flow assay, ELISA, latex-based assays, etc. With the successful completion of numerous projects, Creative Biolabs is confident in providing services and products of the best quality.

If you are interested in the services we provide, please don't hesitate to contact us or directly send us an inquiry. We will get in touch with you as soon as possible.

Reference

  1. Lee M., (2018). “Tissue-specific Role of CX3CR1 Expressing Immune Cells and Their Relationships with Human Disease.” Immune network, 18(1).


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