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The Role of FAM83B in EGFR/RAS Signaling
It has recently been reported that the sequence similarity 83, member B (FAM83B) was identified as novel transforming oncogenes, functioning as intermediaries in aberrant EGFR/RAS signaling. FAM83B is actually highly expressed in several cancer tissues, such as lung cancer. FAM83B can facilitate its role as a signaling oncoprotein by interacting with a noteworthy list of signaling proteins. As overexpressed in many cancers, the novel FAM83 family of signaling proteins has emerged as important therapeutic targets as they function as key intermediates in EGFR, MAPK and PI3K/AKT signaling. FAM83B activates both MAPK, PI3K/AKT/mTOR signaling and cancer-associated Wnt signaling. The involvement of FAM83B in multiple signaling pathways strengthens its potential for precision therapeutic targeting and might be a critical cancer-related biomarker for lung cancer.
Fig.1 Key signaling pathways of FAM83 family of proteins promoting ErbB receptor signaling. (Bartel, C. A., 2016)
FAM83B as a Candidate Marker for Lung Cancer
In the related study, FAM83B expression was intensively examined in some of the specimens in lung cancer by gene expression analysis and western blotting, and then all clinical samples were evaluated by immunohistochemistry (IHC). Both the mRNA and protein level expression of FAM83B was found highly expressed in lung SCC rather than in lung adenocarcinoma or adjacent non-cancer regions. More importantly, higher FAM83B expression evaluated by IHC was associated with longer DFS. FAM83B acts as a candidate marker for lung cancer through a comprehensive gene expression analysis and examined its correlations with various clinicopathological factors. A microarray data set indicated that FAM83B expression was associated with specific cancer subtypes, increased tumor grade, and decreased OS. Additionally, examining FAM83B protein level, and further research provides significant evidence that FAM83B is a candidate biomarker to predict prognosis of SCC and associated with better prognosis of SCC. Hence, FAM83B has been served as the high-efficient marker for the diagnosis of lung cancer and shows the potential target for the therapy.
Fig.2 The family with sequence similarity 83 member B (FAM83B) expression in lung cancer and adjacent normal tissue by IHC. Scale bars, 100 μm. (Okabe, N., 2015)
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References
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