Creative Biolabs is a world-leading service provider in the field of in vitro diagnostic (IVD) antibody development and immunoassay development. In particular, we offer IVD antibody development services targeting the protein C marker. We are committed to providing the highest quality of custom services and products at the most reasonable prices.
Introduction of Protein C
Protein C is a natural, hepatically synthesized serine protease, the activated form of which plays a critical role in regulating anticoagulation, inflammation, cell death, and maintaining the permeability of blood vessel walls. Protein C couples with its receptor, EPCR, and the ligand-receptor complex then interacts with thrombin-thrombomodulin on endothelial surfaces to produce activated protein C (APC). Once activated, APC can perform these operations primarily by proteolytically inactivating protein factor VIIIa, the cofactor for factor IXa-induced factor X activation, and factor Va, the cofactor for factor Xa-induced prothrombin activation. Besides, APC also has been found to inhibit plasminogen activator inhibitor-1 (PAI-1), thus preventing the blockade of endogenous tissue-plasminogen activator (t-PA) and facilitating fibrinolysis.
Fig.1 Protein C anticoagulant pathway. C, protein C; S, protein S.
Protein C for Sepsis Prognosis
A review by Jr et al. (2000) summarized published research articles to consider the appropriateness of protein C levels as a prognostic indicator for sepsis and related diseases. A study by Boldt et al. (2000) illustrates that serial protein C measurement may be a helpful biomarker to differentiate sepsis from other causes of critical illness, such as trauma and neurosurgery. Moreover, numerous studies have shown that acquired protein C deficiency is prevalent in the majority of septic patients and is associated with increased morbidity and mortality in patients with severe sepsis and septic shock. This deficiency in protein C is not simply a transient marker for sepsis but parallels the progress of the disease. Additionally, protein C deficiency occurs in the presence of a wide range of infectious microorganisms (Gram-negative bacteria, Gram-positive bacteria, and parasites) and develops early in the disease process. These findings suggest that protein C levels may serve as a useful prognostic indicator of outcome in sepsis.
Features of IVD Antibody Development Services
To aid in the prognosis and diagnosis of sepsis, Creative Biolabs offers an extensive range of IVD antibody development services against protein C antigens to measure its levels clinically. The features of our services include:
Creative Biolabs provides IVD antibody development services against an extensive range of sepsis biomarkers in addition to Protein C. During antibody development, we work hand in hand with you and your team to ensure project goals and timelines are being met. Contact us to discuss your projects and experience the great value of our expert services.
References
For Research Use Only.
