Creative Biolabs is one of the leading custom antibody generation and development providers. We specialize in the generation of antibodies against a wide range of targets for R&D, diagnostic, and therapeutic applications. Currently, we have launched a series of in vitro diagnostic (IVD) antibody development services targeting numerous diagnostic biomarkers of human diseases. Here, we focus on the spleen tyrosine kinase (Syk) as a marker of lymph cancer.
Spleen Tyrosine Kinase (Syk)
Spleen tyrosine kinase (Syk) is an enzyme that is encoded by the SYK gene in humans. Together with Zap-70, SYK belongs to the Syk family of tyrosine kinases. These non-receptor cytoplasmic tyrosine kinases share a characteristic dual SH2 domain that is separated by a linker region. However, activation of SYK relies less on phosphorylation of the Src family kinase than Zap-70. Although Syk and Zap-70 are mainly expressed in hematopoietic tissues, Syk is expressed in various tissues. In B and T cells, Syk and Zap-70 transmit signals from B-cell receptors and T-cell receptors, respectively. Syk plays a similar role in transmitting signals from various cell surface receptors including CD74, Fc receptors, and integrins.
Fig.1 Structure of the SYK protein.
Syk Marker of Lymph Cancer
In general, the lymphatic system and the blood system are strictly separated. However, in Syk-deficient mice, lymphatic and vascular formation is abnormally shunted, leading to blood leaking into the lymphatic system. The reason for this phenotype was determined by the genetic fate mapping method, which indicates that Syk is expressed in myeloid cells and that it coordinates the proper separation of the lymphatic and hematological systems during and after embryogenesis. The Syk-knockout mice died during embryonic development around midgestation. They show serious defects in the development of the lymphatic system. Therefore, Syk is an important regulator of lymphatic development.
The abnormal function of Syk is associated with several cases of hematopoietic malignancy, including translocations involving Tel and Itk. Constitutive Syk activity can transform B cells. Given the central role of SYK in the transmission of activating signals within B-cells, inhibition of this tyrosine kinase may be useful in the treatment of B-cell malignancies and autoimmune diseases. Syk inhibition has been proposed as a treatment for lymphoma and chronic lymphocytic leukemia.
IVD antibodies are extensively used in immunodiagnostic tools for disease screening and therapeutic monitoring. Through our role as a leading antibody service provider, Creative Biolabs is well-positioned to develop high-quality Syk-specific antibodies. Besides antibody generation, Creative Biolabs also offers diagnostic immunoassay development services, including feasibility analysis, assay design, assay protocol establishment, assay optimization, and kit production.
Creative Biolabs has successfully completed a number of IVD antibody generation and development projects for clients across the globe. If you are interested in our services, please contact us to discuss your project needs.
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