L1 cell adhesion molecule (L1CAM) has been suggested as a biomarker that may discriminate a subset of highly aggressive tumors. As a global specialized contract research organization (CRO), Creative Biolabs provides high-quality L1CAM protein analytical services to support research of native biomarkers. We hope to help you accelerate your discovery and partner with you to explore new frontiers in biological science.
Background
L1CAM, a transmembrane glycoprotein of 200-220 KDa, is a neuronal cell adhesion molecule belonging to the immunoglobulin superfamily. L1CAM plays key functions in the development of the nervous system including neuronal migration, differentiation and is also involved in the malignant progression of neoplasia and the metastatic cascade.
In cancer cells, L1CAM promotes cell proliferation, migration, invasion, and metastasis. Overexpression of L1CAM has been reported to be strongly associated with numerous human cancers such as colorectal, gastric, renal, breast cancer, melanoma and endometrial cancer. These indicate that L1CAM is a candidate serum biomarker for some tumors. Variants in the L1CAM gene result in a spectrum of allelic disorders with X-linked inheritance.
Fig.1 Structure of L1CAM.1
Scientific Validity
The extracellular domain of L1CAM can be cleaved from the tumor cell surface by shedding. The process of L1CAM ectodomain shedding enhances cancer cell migration in various extracellular matrix components through autocrine or paracrine binding of integrins. Thus, L1CAM can also be detected as soluble form of L1CAM in the serum and ascites. Besides, studies revealed that circulating autoantibodies against L1CAM could be also used as potential biomarkers for early detection of ESCC.
Services at Creative Biolabs
Creative Biolabs is ready to assist with your L1CAM analysis needs with the latest in equipment, technology, and a dedicated team to take on your protein and process support needs. Our biomarker analysis services use approaches embraced by the industry. We have developed antibodies which can recognize the extracellular domain of L1CAM in addition antibody recognizes the full-length form (~220 kDa) and the cleaved form (~140 kDa) of L1CAM. Those antibodies resources could be taken into fully consideration when you make a project plan.
If you are interested in our analysis services, please feel free to contact us for more information.
Reference
- van der Maten, Miriam, et al. "L1 cell adhesion molecule in cancer, a systematic review on domain-specific functions." International journal of molecular sciences 20.17 (2019): 4180. Distributed under Open Access license CC BY 4.0, without modification.
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