Metagenomic sequencing represents a culture-independent approach, empowering the identification and characterization of organisms derived from diverse samples. This method entails the comprehensive analysis of the total DNA extracted from a specified sample, enabling the detection of microorganisms spanning all domains of life and their respective genomic compositions. At Creative Biolabs, our extensive sequencing capacity, coupled with proprietary technology, guarantees highly competitive pricing. Moreover, our vast experience across a broad spectrum of metagenomic projects ensures that our experts are adept at offering tailored bioinformatics solutions.
What is Metagenomic Sequencing?
Metagenomic sequencing has emerged as a revolutionary tool, illuminating the intricate genetic mosaic of entire microbial communities. Unlike traditional genomics, which narrowly focuses on individual organisms, metagenomics embraces the comprehensive complexity of microbial ecosystems. It captures the collective genetic information from all microorganisms residing in a specified environment, whether it's air, water, soil, or even the human gut. Metagenomic sequencing not only provides profound insights into species composition and abundance but also delves deeply into functional genes and metabolic pathways.
Fig.1 The research flowchart.1
Key Features
- Comprehensive Coverage
In a single sequencing run, metagenomic sequencing encapsulates the genetic blueprint of all microorganisms present in the environment, furnishing a more extensive and detailed species profile.
- Higher Accuracy
Metagenomic sequencing does not require PCR amplification, thereby objectively restoring the microbial community structure and reflecting the true survival state of microorganisms.
- Higher Resolution
Metagenomic sequencing via assembly technology enables the acquisition of longer gene sequences, providing higher resolution for species annotation.
- Expanded Research Scope
In addition to species-level research, metagenomic sequencing enables studies at the gene and functional levels, significantly expanding the scope of research into microbial functional metabolism.
- Insightful Innovations
Metagenomic sequencing enables the discovery of novel microbes, genes, and metabolic pathways, fostering innovations in medicine, ecology, and biotechnology.
Detailed Procedures
Applications
- Human Health
Gain insight into the role of the microbiome in conditions like inflammatory bowel disease and mental health, thereby facilitating the development of personalized medical treatments.
- Environmental Monitoring
Assessing microbial contamination in water, soil, and air. Identifying biodiversity hotspots and tracking ecosystem changes due to climate or anthropogenic impacts.
- Agriculture and Food Safety
Enhancing crop resilience through microbial inoculants. Detecting foodborne pathogens and ensuring food safety.
- Industrial Applications
Discovering novel enzymes and biocatalysts for industrial processes. Developing microbial-based solutions for bioremediation and waste management.
- Pharmaceuticals
Mining metagenomes for new antibiotics and other therapeutic compounds. Understanding host-microbe interactions to improve drug efficacy and reduce side effects.
Metagenomic sequencing allows for comprehensive sequencing and analysis of genetic material in complex samples. Creative Biolabs is dedicated to providing world-class metagenomic sequencing services to clients globally. Please reach out our sequencing team for professional assistance in designing your project.
Reference
- Li, Lihua, et al. "Metagenomic shotgun sequencing and metabolomic profiling identify specific human gut microbiota associated with diabetic retinopathy in patients with type 2 diabetes." Frontiers in Immunology 13 (2022): 943325. Distributed under Open Access license CC BY 4.0, without modification.
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