Cancer Signaling Phospho Antibody Array features 269 high-specificity antibodies targeting key nodes in cancer-associated signaling pathways, optimized for protein phosphorylation profiling in human, mouse, and rat cancer cell and tissue samples. Each kit includes two identical array slides, enabling parallel analysis of two independent samples, such as a untreated control and a treated experimental specimen.
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Product Property | |
|---|---|
| Species Reactivity | Human; Mouse; Rat |
| Sample Type | Cell lysate; Tissue lysate |
| Assay Type | Fluorescent Immunoassay |
| Detection Method | Fluorescence Scanning |
| Internal Controls | Beta-actin; GAPDH; Negative controls |
| Principle | Fluorescent immunoassay based on antibody microarray, for quantitative detection of cancer pathway phosphorylation levels. |
| Platform | Fluorescent Antibody Microarray |
| Specificity | Human |
| Cross-Reaction | Mouse; Rat |
| Product Content | 2 array slides per package for analyzing two samples (control vs. treated) |
| Slide Dimensions | 76 x 25 x 1 mm |
| Application Notes | ELISA based antibody array |
| Core Highlights | Site-specific phosphorylation profiling and screening with 269 antibodies Antibodies covalently immobilized on 3D polymer coated glass slide Six replicates per antibody Fluorescent detection |
| Signaling Pathway | Cancer Signaling Pathway |
| Storage | 2-8°C |
Target Information | |
|---|---|
| Analyte | Cancer Pathway Phosphoproteins |
| Targets | 14-3-3 zeta (Ser58), 4E-BP1 (Thr36), AKT (Ser473), AKT (Thr308), AKT2 (Ser474), AMPK1 (Thr174), BAD (Ser112), BAD (Ser136), BAD (Ser155), BCL2 (Ser70), BCL2 (Thr56), BCL-XL (Ser62), BRCA1 (Ser1423), BRCA1 (Ser1524), CaMK2 (Thr286), Catenin b (Ser33), Catenin b (Ser37), Catenin b (Thr41/Ser45), Caspase 3 (Ser150), Caspase 9 (Ser144), Caspase 9 (Thr125), Caspase 9 (Tyr153),Caveolin-1 (Tyr14), CDC2 (Tyr15), CDC25A (Ser75), CDC25C (Ser216), CDK2 (Thr160), Chk1 (Ser280), Chk1 (Ser317), Chk1 (Ser345), Chk2 (Ser516), Chk2 (Thr68), c-Jun (Thr239), c-Jun (Ser243), c-Jun (Ser73), c-Kit (Tyr721), CREB (Ser133), CrkII (Tyr221), eEF2K (Ser366), EGFR (Tyr1110), eIF2A (Ser51), eIF4E (Ser209), Elk1 (Ser383), ERK3 (Ser189), ERK8 (Thr175/Tyr177), Estrogen Receptor-a (Ser167), FAK (Tyr397), FAK (Tyr861), FAK (Tyr925), FGFR1 (Tyr154), FKHR (Ser256), GSK3 alpha (Ser21), GSK3 beta (Ser9), HDAC8 (Ser39), HER2 (Tyr877), Histone H2A.X (Ser139), HSF1 (Ser303), HSP27 (Ser15), HSP27 (Ser78), HSP90B (Ser254), ICAM-1 (Tyr512), IGF-1R (Tyr1161), IkB-alpha (Ser32/36), IkB-alpha (Tyr42), IkB-beta (Ser23), IkB-epsilon (Ser22), IKK-alpha (Thr23), Integrin beta-3 (Tyr773), Integrin beta-3 (Tyr785), JAK1 (Tyr1022), JAK2 (Tyr1007), JAK2 (Tyr221), JunB (Ser259), JunB (Ser79), JunD (Ser255), Keratin 18 (Ser33), MEK1 (Ser217), MEK1 (Ser221), MEK1 (Thr291), MEK-2 (Thr394), Met (Tyr1349), MKK3 (Ser189), MSK1 (Ser376), mTOR (Ser2448), Myc (Ser62), Myc (Ser373), Myc (Thr358), Myc (Thr58), NFkB-p100/p52 (Ser865), NFkB-p100/p52 (Ser869), NFkB-p105/p50 (Ser893), NFkB-p105/p50 (Ser907), NFkB-p105/p50 (Ser932), NFkB-p65 (Ser529), NFkB-p65 (Thr254), p21Cip1 (Thr145), p27Kip1 (Ser10), p27Kip1 (Thr187), P38 MAPK (Thr180), P38 MAPK (Tyr182), p44/42 MAPK (Thr202), p44/42 MAPK (Tyr204), p53 (Ser6), p53 (Ser315), P70S6K (Ser424), PDGF R beta (Tyr751), PDK1 (Ser241), PI3K p85a (Tyr607), PTEN (Ser380/Thr382/Thr383), Pyk2 (Tyr402), Rac1/cdc42 (Ser71), Raf1 (Ser259), Rb (Ser780), Rel (Ser503), SAPK/JNK (Thr183), Shc (Tyr349), SHP-2 (Tyr580), Smad3 (Ser425), Src (Tyr418), Src (Tyr529), STAT1 (Ser727), STAT1 (Tyr701), STAT3 (Ser727), STAT3 (Tyr705), STAT4 (Tyr693), STAT5A (Ser780), STAT5A (Tyr694), STAT6 (Thr645), STAT6 (Tyr641), Tau (Ser404), Trk B (Tyr515), TYK2 (Tyr1054), VEGFR2 (Tyr951) |
| Target Source | Human; Mouse; Rat |
For Research Use Only.