ErbB/Her Signaling Phospho Antibody Array features 239 high-specificity antibodies targeting key functional proteins in the ErbB/Her signaling pathway, optimized for protein phosphorylation profiling in human, mouse, and rat cell and tissue samples. Each kit includes two identical array slides, enabling parallel analysis of two independent samples, such as a control specimen and a treated experimental sample.
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Product Property | |
|---|---|
| Species Reactivity | Human; Mouse; Rat |
| Sample Type | Cell lysate; Tissue lysate |
| Assay Type | Fluorescent Immunoassay |
| Detection Method | Fluorescence Scanning |
| Internal Controls | Beta-actin; GAPDH; Negative controls |
| Principle | Fluorescent immunoassay based on antibody microarray, for quantitative detection of ErbB pathway phosphorylation levels. |
| Platform | Fluorescent Antibody Microarray |
| Specificity | Human |
| Cross-Reaction | Mouse; Rat |
| Product Content | 2 array slides per package for two samples (untreated vs. treated) |
| Slide Dimensions | 76 x 25 x 1 mm |
| Application Notes | ELISA based antibody array |
| Core Highlights | Site-specific phosphorylation profiling and screening with 239 antibodies Antibodies covalently immobilized on 3D polymer coated glass slide Fluorescent detection |
| Signaling Pathway | ErbB/Her Signaling |
| Storage | 2-8°C |
Target Information | |
|---|---|
| Analyte | ErbB/Her Signaling Phospho |
| Targets | Abl1(Thr754/735), Abl1(Tyr204), AKT(Ser473), AKT(Thr308), AKT(Tyr326), AKT1(Ser124), AKT1(Ser246), AKT1(Thr450), AKT1(Thr72), AKT1(Tyr474), AKT2(Ser474), BAD(Ser112), BAD(Ser134), BAD(Ser136), BAD(Ser155), BAD(Ser91/128), c-Abl(Tyr412), Calmodulin(Thr79/Ser81), CaMK1-a(Thr177), CaMK1-?, CaMK2(Thr305), CaMK2-beta/gamma/delta (Ab-287), CaMK2-beta/gamma/delta(Thr287), CaMK2I(Thr286), CaMK4(Thr196/200), Catenin beta(Ser33), Catenin beta(Ser37), Catenin beta(Thr41/Ser45), Catenin beta(Tyr489), Catenin beta(Tyr654), Caveolin-1(Tyr14), CBL(Tyr700), CBL(Tyr774), CrkII(Tyr221), CrkL(Tyr207), Dok-1(Tyr362), Dok-1(Tyr398), Dok-2(Tyr299), E-Cadherin, EGFR(Ser1070), EGFR(Thr678), EGFR(Thr693), EGFR(Tyr1016), EGFR(Tyr1069), EGFR(Tyr1092), EGFR(Tyr1110), EGFR(Tyr1172), EGFR(Tyr1197), EGFR(Tyr869), FAK(Ser910), FAK(Tyr397), FAK(Tyr407), FAK(Tyr576), FAK(Tyr861), FAK(Tyr925), FKHR(Ser256), FKHR(Ser319), FOXO1/3/4-PAN(Thr24/32), FOXO1A(Ser329), Gab1(Tyr627), Gab1(Tyr659), Gab2(Tyr643), GSK3alpha(Ser21), GSK3alpha/beta(Tyr216/279), GSK3beta(Ser9), HER2(Tyr1221/Tyr1222), HER2(Tyr1248), HER2(Tyr877), HER3/ErbB3(Tyr1222), HER3/ErbB3(Tyr1289), HER4/ErbB4(Tyr1284), JAK1(Tyr1022), JAK2(Tyr1007), JAK2(Tyr221), JNK1/2/3(Thr183/Tyr185), MAP3K1/MEKK1(Thr1381), MDM2(Ser166), MEF2A(Ser408), MEF2A(Thr312), MEF2A(Thr319), mTOR(Ser2448), mTOR(Ser2481), mTOR(Thr2446), NMDAR1(Ser897), NMDAR2B(Tyr1472), p130Cas(Tyr165), p130Cas(Tyr410), p44/42 MAP Kinase(Thr202), p44/42 MAP Kinase(Tyr204), p53(Ser15), p53(Ser392), P70S6K(Ser371), P70S6K(Ser424), P70S6K(Thr229), P70S6K-beta(Ser423), PAK1(Ser204), PAK1(Thr212), PAK1/2(Ser199), Paxillin(Tyr118), Paxillin(Tyr31), PI3-kinase p85-alpha(Tyr607), PI3-kinase p85-subunit alpha/gamma(Tyr467/Tyr199), PKC pan activation site, PLC-gamma 1(Tyr771), PLC-gamma 1(Tyr783), PLC-gamma 2(Tyr1217), PLC-gamma 2(Tyr753), Rac1/cdc42(Ser71), Raf1(Phospho-Ser621), Raf1(Ser259), Raf1(Ser338), Raf1(Tyr341), Shc(Tyr349), Shc(Tyr427), SHP-2(Tyr542), SHP-2(Tyr580), Src(Ser75), Src(Tyr418), Src(Tyr529), SYK(Tyr348), SYK(Tyr525), VAV1(Tyr174), XIAP(Ser87) |
| Target Source | Human; Mouse; Rat |
For Research Use Only.