Human AFP antibody pair set for ELISA; ICT; CLIA useCapture Antibody: Mouse Monoclonal IgGDetection Antibody: Mouse Monoclonal IgG
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Antigen Detail | |
|---|---|
| Target | AFP |
| Description | This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Mouse |
| Immunogen | Human Alpha-fetoprotein Protein, native protein |
| Clone | IV01394 |
| Isotype | IgG |
| Purification | Affinity Chromatography |
| Buffer | 0.02M PBS, pH7.4,with 0.1% NaN3 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Mouse |
| Conjugation | Unconjugated |
| Clone | RD1048 |
| Isotype | IgG |
| Purification | Affinity Chromatography |
| Buffer | 0.02M PBS, pH7.4, containing 0.1% NaN3 |
General Product Property | |
|---|---|
| Product Overview | Human AFP antibody pair set for ELISA; ICT; CLIA use Capture Antibody: Mouse Monoclonal IgG Detection Antibody: Mouse Monoclonal IgG |
| Specificity | Both the capture and the detection antibodies in this set react with human AFP. |
| Research Area | Inflammation |
| Application | ELISA; ICT; CLIA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Liquid |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Plasma; Serum; Cell Culture Supernatant |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | AFP |
| Full Name | Alpha Fetoprotein |
| Background | This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008] |
| Alternative Names | Alpha Fetoprotein; Alpha-1-Fetoprotein; Alpha-Fetoglobulin; HPAFP; Alpha-Fetoprotein; AFPD; FETA; |
| Gene ID | 174 (Human); 11576 (Mouse) |
| Uniprot ID | P02771 (Human); P02772 (Mouse) |
| GeneCards | AFP |
| HGNC | 317 |
| Ensembl | ENSG00000081051 |
| OMIM | 104150 |
| Involvement in Disease | Diseases associated with AFP include Alpha-Fetoprotein Deficiency and Alpha-Fetoprotein, Hereditary Persistence Of. |
| Function | The combination of copper, nickel and fatty acids and bilirubin is not as good as serum albumin. Only a small percentage (less than 2%) of human AFP show estrogen binding properties. |
| Related Pathways | Its related pathways are FOXA2 and FOXA3 transcription factor networks and Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers. |
For Research Use Only.
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