Human AMOT Matched Antibody Pair set for ELISA useCapture Antibody: Rabbit purified polyclonal anti-AMOTDetection Antibody: Mouse polyclonal anti-AMOT
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Antigen Detail | |
|---|---|
| Target | AMOT |
| Description | Angiomotin (AMOT) is a protein that in humans is encoded by the AMOT gene. It belongs to the motin family of angiostatin binding proteins, which includes angiomotin, angiomotin-like 1 (AMOTL1) and angiomotin-like 2 (AMOTL2) characterized by coiled-coil domains at N-terminus and consensus PDZ-binding domain at the C-terminus. Angiomotin is expressed predominantly in endothelial cells of capillaries as well as angiogenic tissues such as placenta and solid tumor. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Polyclonal |
| Host Species | Rabbit |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Polyclonal |
| Host Species | Mouse |
| Conjugation | Unconjugated |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human AMOT Matched Antibody Pair set for ELISA use Capture Antibody: Rabbit purified polyclonal anti-AMOT Detection Antibody: Mouse polyclonal anti-AMOT |
| Specificity | Validated for detecting natural and recombinant human AMOT |
| Research Area | Cell Biology |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | AMOT |
| Full Name | Angiomotin |
| Background | This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| Alternative Names | Angiomotin; Angiomotin P130 Isoform |
| Gene ID | 154796 |
| Uniprot ID | Q4VCS5 |
| HGNC | 17810 |
| Ensembl | ENSG00000126016 |
| OMIM | 300410 |
| Involvement in Disease | Diseases associated with AMOT include Papilloma and Myeloproliferative Syndrome, Transient. |
| Function | Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. |
| Related Pathways | Its related pathways are Signaling by GPCR and Signaling by Hippo. |
For Research Use Only.
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