Human CALCOCO2 Matched Antibody Pair set for ELISA useCapture Antibody: Rabbit purified polyclonal anti-CALCOCO2Detection Antibody: Mouse purified polyclonal anti-CALCOCO2
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Antigen Detail | |
|---|---|
| Target | CALCOCO2 |
| Description | CALCOCO2, also named as NDP52, is an autophagy receptor. It plays a role in ruffle formation and actin cytoskeleton organization. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Polyclonal |
| Host Species | Rabbit |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Polyclonal |
| Host Species | Mouse |
| Conjugation | Unconjugated |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human CALCOCO2 Matched Antibody Pair set for ELISA use Capture Antibody: Rabbit purified polyclonal anti-CALCOCO2 Detection Antibody: Mouse purified polyclonal anti-CALCOCO2 |
| Specificity | Validated for detecting natural and recombinant human CALCOCO2 |
| Research Area | Immune System Diseases |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | CALCOCO2 |
| Full Name | Calcium Binding And Coiled-Coil Domain 2 |
| Background | This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a receptor for ubiquitin-coated bacteria and plays an important role in innate immunity by mediating macroautophagy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| Alternative Names | NDP52; Calcium-Binding And Coiled-Coil Domain-Containing Protein 2; Antigen Nuclear Dot 52 KDa Protein |
| Gene ID | 10241 |
| Uniprot ID | Q13137 |
| GeneCards | CALCOCO2 |
| HGNC | 29912 |
| Ensembl | ENSG00000136436 |
| OMIM | 604587 |
| Involvement in Disease | Diseases associated with CALCOCO2 include Influenza and Inflammatory Bowel Disease 19. |
| Function | Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994). |
| Related Pathways | Its related pathways are Shigellosis and Mitophagy - animal. |
For Research Use Only.
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