Human CD200R antibody pair set for sandwich ELISA useCapture Antibody: Monoclonal IgGDetection Antibody: Unconjugated-Rabbit Monoclonal IgG
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Antigen Detail | |
|---|---|
| Target | CD200R |
| Description | Cell surface transmembrane glycoprotein CD200 receptor 1 is a protein that in humans is encoded by the CD200R1 gene.[5][6][7] CD200R1 is expressed on the surface of myeloid cells[8] and CD4+ T cells.[9] It interacts with CD200 transmembrane glycoprotein that can be expressed on variety of cells including neurons,[10] epithelial cells,[11] endothelial cells,[12] fibroblasts,[13] and lymphoid cells.[14] |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone | IV01715 |
| Isotype | IgG |
| Purification | Affinity Chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Rabbit |
| Conjugation | Unconjugated |
| Clone | RD1021 |
| Isotype | IgG |
| Purification | Affinity Chromatography |
| Buffer | PBS, pH 7.4, BSA and Azide free |
General Product Property | |
|---|---|
| Product Overview | Human CD200R antibody pair set for sandwich ELISA use Capture Antibody: Monoclonal IgG Detection Antibody: Unconjugated-Rabbit Monoclonal IgG |
| Specificity | Both the capture and the detection antibodies in this set react with Human CD200R . |
| Range | 46.875 pg/mL-3000 pg/mL |
| Research Area | Immunology; Cell Biology; Cancer; Inflammation |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Liquid |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Plasma; Serum; Cell Culture Supernatant |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | CD200R1 |
| Full Name | Cell surface transmembrane glycoprotein CD200 receptor 1 |
| Background | Cell surface transmembrane glycoprotein CD200 receptor 1 is a protein that in humans is encoded by the CD200R1 gene.[5][6][7] CD200R1 is expressed on the surface of myeloid cells[8] and CD4+ T cells.[9] It interacts with CD200 transmembrane glycoprotein that can be expressed on variety of cells including neurons,[10] epithelial cells,[11] endothelial cells,[12] fibroblasts,[13] and lymphoid cells.[14] |
| Alternative Names | CD200R1; CD200R; HCRTR2; MOX2R; OX2R; CD200 receptor 1 |
| Gene ID | 131450 |
| Uniprot ID | Q8TD46 |
| GeneCards | CD200R1 |
| HGNC | 24235 |
| Ensembl | ENSG00000163606 |
| OMIM | 607546 |
| Involvement in Disease | Diseases associated with CD200R1 include Human Herpesvirus 8 and Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1. |
| Function | Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200. |
For Research Use Only.
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