Human DDR1 antibody pair set for ELISA useCapture Antibody: rabbit anti-DDR1 monoclonal antibodyDetection Antibody: rabbit anti-DDR1 monoclonal antibody conjugated to HRP
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Antigen Detail | |
|---|---|
| Target | DDR1 |
| Description | Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 10 (MCK10), belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. Expression of DDR1/MCK10/CD167 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. DDR1/MCK10/CD167 plays an important role in regulating attachment to collagen, chemotaxis, proliferation, and MMP production in smooth muscle cells. DDR1 functions in a feedforward loop to increase p53 levels and at least some of its effectors. Inhibition of DDR1 function resulted in strikingly increased apoptosis of wild-type p53-containing cells in response to genotoxic stress through a caspase-dependent pathway. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone | IV01966 |
| Purification | Affinity Chromatography |
| Buffer | Prior to lyophilization: PBS, pH 7.4 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Rabbit |
| Conjugation | HRP |
| Clone | RD10146 |
| Purification | Affinity Chromatography |
| Buffer | Prior to lyophilization: PBS, containing 50 % HRP-Protector |
General Product Property | |
|---|---|
| Product Overview | Human DDR1 antibody pair set for ELISA use Capture Antibody: rabbit anti-DDR1 monoclonal antibody Detection Antibody: rabbit anti-DDR1 monoclonal antibody conjugated to HRP |
| Specificity | Quantitative determination of Human DDR1 |
| Range | 56.25-3600 pg/mL |
| Research Area | Neurotransmission |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | DDR1 |
| Full Name | Discoidin domain receptor family, member 1 |
| Background | Discoidin domain receptor family member 1, also known as DDR1 or CD167a (differentiation cluster 167a), is a human gene. Receptor tyrosine kinase (RTK) plays a key role in the communication between cells and their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is RTK, which is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to the subfamily of tyrosine kinase receptors, and is homologous to the discoidin I protein in its extracellular domain. To date, all tested collagen (Type I to Type VI) can be autophosphorylated. |
| Alternative Names | DDR1; CAK; CD167; DDR; EHGK2; MCK10; NEP; NTRK4; PTK3; PTK3A; RTK6; TRKE; discoidin domain receptor tyrosine kinase 1 |
| Gene ID | 780 |
| Uniprot ID | Q08345 |
For Research Use Only.
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