Human DPT antibody pair set for sandwich ELISA useCapture Antibody: Monoclonal IgGDetection Antibody: Unconjugated-Rabbit Monoclonal IgG
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Antigen Detail | |
|---|---|
| Target | DPT |
| Description | Dermatopontin also known as tyrosine-rich acidic matrix protein (TRAMP) is a protein that in humans is encoded by the DPT gene.[5][6] Dermatopontin is a 22-kDa protein of the noncollagenous extracellular matrix (ECM) estimated to comprise 12 mg/kg of wet dermis weight.[7] To date, homologues have been identified in five different mammals and 12 different invertebrates with multiple functions.[8] In vertebrates, the primary function of dermatopontin is a structural component of the ECM (interaction with decorin and modification of collagen fibrillogenesis), cell adhesion, modulation of TGF-β activity and cellular quiescence). It also has pathological involvement in heart attacks (increased expression around myocardial infarct zone) and decreased expression in leiomyoma and fibrosis. In invertebrate, dermatopontin homologue plays a role in hemagglutination, cell-cell aggregation, and expression during parasite infection. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone | IV01533 |
| Isotype | IgG |
| Purification | Affinity Chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Rabbit |
| Conjugation | Unconjugated |
| Clone | RD10266 |
| Isotype | IgG |
| Purification | Affinity Chromatography |
| Buffer | PBS, pH 7.4, BSA and Azide free |
General Product Property | |
|---|---|
| Product Overview | Human DPT antibody pair set for sandwich ELISA use Capture Antibody: Monoclonal IgG Detection Antibody: Unconjugated-Rabbit Monoclonal IgG |
| Specificity | Both the capture and the detection antibodies in this set react with Human DPT . |
| Range | 18.75 pg/mL-1200 pg/mL |
| Research Area | Immunology; Cell Biology; Cancer; Inflammation |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Liquid |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Plasma; Serum; Cell Culture Supernatant |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | DPT |
| Full Name | Dermatopontin |
| Background | Dermatopontin also known as tyrosine-rich acidic matrix protein (TRAMP) is a protein that in humans is encoded by the DPT gene.[5][6] Dermatopontin is a 22-kDa protein of the noncollagenous extracellular matrix (ECM) estimated to comprise 12 mg/kg of wet dermis weight.[7] To date, homologues have been identified in five different mammals and 12 different invertebrates with multiple functions.[8] In vertebrates, the primary function of dermatopontin is a structural component of the ECM (interaction with decorin and modification of collagen fibrillogenesis), cell adhesion, modulation of TGF-β activity and cellular quiescence). It also has pathological involvement in heart attacks (increased expression around myocardial infarct zone) and decreased expression in leiomyoma and fibrosis. In invertebrate, dermatopontin homologue plays a role in hemagglutination, cell-cell aggregation, and expression during parasite infection. |
| Alternative Names | DPT; TRAMP; dermatopontin |
| Gene ID | 1805 |
| Uniprot ID | Q07507 |
| GeneCards | DPT |
| HGNC | 3011 |
| Ensembl | ENSG00000143196 |
| OMIM | 125597 |
| Involvement in Disease | Diseases associated with DPT include Cycloplegia and Regular Astigmatism. |
| Function | Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation |
For Research Use Only.
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