Human EIF2B2 Matched Antibody Pair set for ELISA useCapture Antibody: Mouse monoclonal anti-EIF2B2Detection Antibody: Rabbit purified polyclonal anti-EIF2B2
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Antigen Detail | |
|---|---|
| Target | EIF2B2 |
| Description | Translation initiation factor eIF-2B subunit beta is a protein that in humans is encoded by the EIF2B2 gene. The eIF2B protein helps regulate overall protein production (synthesis) in the cell by interacting with another protein, eIF2. Mutations in the EIF2B2 gene have been identified in a few people with leukoencephalopathy with vanishing white matter, including some affected females with a variant of the disorder in which the neurological features are accompanied by ovarian failure (ovarioleukodystrophy). These mutations cause partial loss of eIF2B function. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Mouse |
| Clone | IV0197 |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Polyclonal |
| Host Species | Rabbit |
| Conjugation | Unconjugated |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human EIF2B2 Matched Antibody Pair set for ELISA use Capture Antibody: Mouse monoclonal anti-EIF2B2 Detection Antibody: Rabbit purified polyclonal anti-EIF2B2 |
| Specificity | Validated for detecting natural and recombinant human EIF2B2 |
| Research Area | Transcription |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | EIF2B2 |
| Full Name | Eukaryotic Translation Initiation Factor 2B Subunit Beta |
| Background | This gene encodes the beta subunit of eukaryotic initiation factor-2B (EIF2B). EIF2B is involved in protein synthesis and exchanges GDP and GTP for its activation and deactivation. |
| Alternative Names | Translation Initiation Factor EIF-2B Subunit Beta; EIF-2Bbeta; EIF2BB |
| Gene ID | 8892 |
| Uniprot ID | P49770 |
| GeneCards | EIF2B2 |
| HGNC | 3258 |
| Ensembl | ENSG00000119718 |
| OMIM | 606454 |
| Involvement in Disease | Diseases associated with EIF2B2 include Leukoencephalopathy With Vanishing White Matter and Premature Ovarian Failure 1. |
| Function | Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. |
| Related Pathways | Its related pathways are Viral mRNA Translation and Beta-Adrenergic Signaling. |
For Research Use Only.
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