Human EIF5A2 Matched Antibody Pair set for ELISA useCapture Antibody: Rabbit purified polyclonal anti-EIF5A2Detection Antibody: Mouse polyclonal anti-COMT
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Antigen Detail | |
|---|---|
| Target | EIF5A2 |
| Description | Eukaryotic translation initiation factor 5A-2 is a protein that in humans is encoded by the EIF5A2 gene. Overexpression of EIF-5A2 is an independent predictor of outcome in patients of urothelial carcinoma of the bladder treated with radical cystectomy. Increased expression of EIF-5A2 in ovarian carcinoma may represent an acquired malignant phenotypic feature of tumor cells. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Polyclonal |
| Host Species | Rabbit |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Mouse |
| Conjugation | Unconjugated |
| Clone | RD10376 |
| Isotype | IgG1, kappa |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human EIF5A2 Matched Antibody Pair set for ELISA use Capture Antibody: Rabbit purified polyclonal anti-EIF5A2 Detection Antibody: Mouse polyclonal anti-COMT |
| Specificity | Validated for detecting natural and recombinant human EIF5A2 |
| Research Area | Transcription |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | EIF5A2 |
| Full Name | Eukaryotic Translation Initiation Factor 5A2 |
| Alternative Names | EIF-5A-2; EIF-5A2; EIF5AII |
| Gene ID | 56648 |
| Uniprot ID | Q9GZV4 |
| GeneCards | EIF5A2 |
| HGNC | 3301 |
| Ensembl | ENSG00000163577 |
| OMIM | 605782 |
| Involvement in Disease | Diseases associated with EIF5A2 include Colorectal Cancer. |
| Function | mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity). |
| Related Pathways | Its related pathways are Metabolism of proteins and Gamma carboxylation, hypusine formation and arylsulfatase activation. |
For Research Use Only.
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