Human ENG Matched Antibody Pair set for ELISA useCapture Antibody: Rabbit purified polyclonal anti-ENGDetection Antibody: Mouse monoclonal anti-ENG, IgG1 Kappa
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Antigen Detail | |
|---|---|
| Target | ENG |
| Description | Endoglin (ENG) is a type I membrane glycoprotein located on cell surfaces and is part of the TGF beta receptor complex. It is also commonly referred to as CD105, END, FLJ41744, HHT1, ORW and ORW1. It has a crucial role in angiogenesis, therefore, making it an important protein for tumor growth, survival and metastasis of cancer cells to other locations in the body. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Polyclonal |
| Host Species | Rabbit |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Mouse |
| Conjugation | Unconjugated |
| Clone | RD10429 |
| Isotype | IgG1, kappa |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human ENG Matched Antibody Pair set for ELISA use Capture Antibody: Rabbit purified polyclonal anti-ENG Detection Antibody: Mouse monoclonal anti-ENG, IgG1 Kappa |
| Specificity | Validated for detecting natural and recombinant human ENG |
| Research Area | Angiogenesis |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | ENG |
| Full Name | Endoglin |
| Background | The CD133 antigen, also known as prominin-1, is a glycoprotein encoded by the PROM1 gene in humans. It is a member of pentaspan transmembrane glycoprotein, which is specifically located in the cell protrusion. When embedded in the cell membrane, the membrane topology of prominin-1 extends the N-terminus into the extracellular space, while the C-terminus is located in the intracellular compartment. The protein consists of five transmembrane fragments, of which the first and second fragments and the third and fourth fragments are connected by an intracellular loop, and the second and third and fourth and fifth and transmembrane fragments are by an extracellular loop Connected. |
| Alternative Names | PROM1 |
| Gene ID | 2022 |
| Uniprot ID | P17813 |
| GeneCards | ENG |
| HGNC | 3349 |
| Ensembl | ENSG00000106991 |
| OMIM | 131195 |
| Involvement in Disease | Diseases associated with ENG include Telangiectasia, Hereditary Hemorrhagic, Type 1 and Hereditary Hemorrhagic Telangiectasia. |
| Function | Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529). Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells (PubMed:17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed:1692830). Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:8370410, PubMed:21737454, PubMed:22347366, PubMed:23300529). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed:21737454, PubMed:22347366, PubMed:23300529). |
| Related Pathways | Its related pathways are Mesenchymal Stem Cells and Lineage-specific Markers and Hematopoietic Stem Cells and Lineage-specific Markers. |
For Research Use Only.
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