Human EPB41 Matched Antibody Pair set for ELISA useCapture Antibody: Mouse monoclonal anti-EPB41Detection Antibody: Rabbit purified polyclonal anti-EPB41
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Antigen Detail | |
|---|---|
| Target | EPB41 |
| Description | Protein 4.1, also known as Beatty's Protein, is a protein associated with the cytoskeleton that in humans is encoded by the EPB41 gene. Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Protein 4.1 (80 kD) interacts with spectrin and short actin filaments to form the erythrocyte membrane skeleton. Mutations of spectrin and protein 4.1 are associated with elliptocytosis or spherocytosis and anemia of varying severity. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Mouse |
| Clone | IV01480 |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Polyclonal |
| Host Species | Rabbit |
| Conjugation | Unconjugated |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human EPB41 Matched Antibody Pair set for ELISA use Capture Antibody: Mouse monoclonal anti-EPB41 Detection Antibody: Rabbit purified polyclonal anti-EPB41 |
| Specificity | Validated for detecting natural and recombinant human EPB41 |
| Research Area | Cytoskeleton |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | EPB41 |
| Full Name | Erythrocyte Membrane Protein Band 4.1 |
| Background | The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| Alternative Names | Protein 4.1 |
| Gene ID | 2035 |
| Uniprot ID | P11171 |
| GeneCards | EPB41 |
| HGNC | 3377 |
| Ensembl | ENSG00000159023 |
| OMIM | 130500 |
| Involvement in Disease | Diseases associated with EPB41 include Elliptocytosis 1 and Hereditary Elliptocytosis. |
| Function | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). |
| Related Pathways | Its related pathways are Syndecan-2-mediated signaling events and Protein-protein interactions at synapses. |
For Research Use Only.
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