Human FAAH Matched Antibody Pair set for ELISA useCapture Antibody: Mouse monoclonal anti-FAAH, IgG1 KappaDetection Antibody: Mouse monoclonal anti-FAAH, IgG1 Kappa
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Antigen Detail | |
|---|---|
| Target | FAAH |
| Description | Fatty acid amide hydrolase or FAAH is a member of the serine hydrolase family of enzymes. It was first shown to break down anandamide in 1993. In humans, it is encoded by the gene FAAH and mainly present in the pancreas, brain, kidney, skeletal muscle, and placenta. FAAH is a promising target for treating many disease conditions including pain, inflammation and mood disorders. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Mouse |
| Clone | IV01785 |
| Isotype | IgG1, kappa |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Mouse |
| Conjugation | Biotin |
| Clone | RD10231 |
| Isotype | IgG1, kappa |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human FAAH Matched Antibody Pair set for ELISA use Capture Antibody: Mouse monoclonal anti-FAAH, IgG1 Kappa Detection Antibody: Mouse monoclonal anti-FAAH, IgG1 Kappa |
| Specificity | Validated for detecting natural and recombinant human FAAH |
| Research Area | Neurotransmission |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | FAAH |
| Full Name | Fatty Acid Amide Hydrolase |
| Background | This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. |
| Alternative Names | PSAB |
| Gene ID | 2166 |
| Uniprot ID | O00519 |
| HGNC | 3553 |
| Ensembl | ENSG00000117480 |
| OMIM | 602935 |
| Involvement in Disease | Diseases associated with FAAH include Polysubstance Abuse and Cannabis Dependence. |
| Function | Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:9122178, PubMed:17015445, PubMed:19926788). Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (PubMed:9122178, PubMed:17015445). Also catalyzes the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol) (PubMed:21049984). |
| Related Pathways | Its related pathways are GABAergic synapse and Arachidonic acid metabolism. |
For Research Use Only.
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