Human FADD Matched Antibody Pair set for ELISA useCapture Antibody: Rabbit purified polyclonal anti-FADDDetection Antibody: Mouse monoclonal anti-FADD, IgG1 Lambda
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Antigen Detail | |
|---|---|
| Target | FADD |
| Description | Fas-associated protein with death domain, also called MORT1, is encoded by the FADD gene on the 11q13.3 region of chromosome 11 in humans. FADD is an adaptor protein that bridges members of the tumor necrosis factor receptor superfamily, such as the Fas-receptor, to procaspases 8 and 10 to form the death-inducing signaling complex during apoptosis. As well as its most well known role in apoptosis, FADD has also been seen to play a role in other processes including proliferation, cell cycle regulation and development. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Polyclonal |
| Host Species | Rabbit |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Mouse |
| Conjugation | Unconjugated |
| Clone | RD1026 |
| Isotype | IgG1, lambda |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human FADD Matched Antibody Pair set for ELISA use Capture Antibody: Rabbit purified polyclonal anti-FADD Detection Antibody: Mouse monoclonal anti-FADD, IgG1 Lambda |
| Specificity | Validated for detecting natural and recombinant human FADD |
| Research Area | Apoptosis |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | FADD |
| Full Name | Fas-associated protein with death domain |
| Background | Fas-associated protein with death domain (FADD), also called MORT1, is encoded by the FADD gene on the 11q13.3 region of chromosome 11 in humans. |
| Alternative Names | FADD; GIG3; MORT1; Fas associated via death domain |
| Gene ID | 8772 |
| Uniprot ID | Q13158 |
| GeneCards | FADD |
| HGNC | 3573 |
| Ensembl | ENSG00000168040 |
| OMIM | 602457 |
| Involvement in Disease | Diseases associated with FADD include?Infections, Recurrent, With Encephalopathy, Hepatic Dysfunction, And Cardiovascular Malformations?and?Otodental Dysplasia. |
| Function | Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.? |
| Related Pathways | Its related pathways are Apoptosis Modulation and Signaling and Signaling by GPCR. |
For Research Use Only.
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