Name: Human G-CSF ELISA Matched Antibody Pair Set [ABP-Q-04-122]
SKU: ABP-Q-04-122
Price: 919.6 USD

Human G-CSF ELISA Matched Antibody Pair Set [ABP-Q-04-122] (CAT#: ABP-Q-04-122)

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Human G-CSF antibody pair set for ELISA useCapture Antibody: rabbit anti-Human G-CSF polyclonal antibodyDetection Antibody: rabbit anti-Human G-CSF monoclonal antibody conjugated to HRP

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Type	Size	Price	Quantity
Antibody Pair Set-Package 1	5 × 96 tests	$919.60
Antibody Pair Set-Package 2	15 × 96 tests	$1,919.66

Datasheet

MSDS

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Lot Number

Antigen Detail
Target	G-CSF
Description	Granulocyte-colony stimulating factor (G-CSF) is a growth factor and an essential cytokine belonging to the CSF family of hormone-like glycoproteins. It is produced by numerous cell types including immune and endothelial cells. G-CSF binding to its receptor G-CSF-R which belongs to the cytokine receptor type I family depends on the interaction of alpha-helical motifs of the former and two fibronectin type III as well as an immunoglobulin-like domain of the latter. Recent animal studies have also revealed that G-CSF activates multiple signaling pathways, such as Akt and also the Janus family kinase-2 and signal transducer and activation of transcription-3 (Jak2-STAT3) pathway, thereby promoting survival, proliferation, differentiation and mobilisation of haematopoietic stem and progenitor cells. G-CSF is a cytokine that have been demonstrated to improve cardiac function and perfusion in myocardial infarction. And it was initially evaluated as a stem cell mobilizer and erythropoietin as a cytoprotective agent. G-CSF prevents left ventricular remodeling after myocardial infarction by decreasing cardiomyocyte death and by increasing the number of blood vessels, suggesting the importance of direct actions of G-CSF on the myocardium rather than through mobilization and differentiation of stem cells. Accordingly, recombinant human (rh)G-CSF has been extensively used in clinical haematology and oncology to enable bone marrow transplantation or to treat chemotherapy-associated neutropenia. In preclinical study, G-CSF improved cardiac function and perfusion by angiomyogenesis and protection of cardiomyocytes in myocardial infarction.
Species Reactivity	Human

Capture Antibody
Capture Clonality	Polyclonal
Host Species	Rabbit
Purification	Affinity Chromatography
Buffer	Prior to lyophilization: PBS, pH 7.4
Application	ELISA

Detection Antibody
Det-Clonality	Monoclonal
Host Species	Rabbit
Conjugation	HRP
Clone	RD10275
Purification	Affinity Chromatography
Buffer	Prior to lyophilization: PBS, containing 50 % HRP-Protector

General Product Property
Product Overview	Human G-CSF antibody pair set for ELISA use Capture Antibody: rabbit anti-Human G-CSF polyclonal antibody Detection Antibody: rabbit anti-Human G-CSF monoclonal antibody conjugated to HRP
Specificity	Quantitative determination of Human G-CSF
Range	93.75-6000 pg/Ml
Research Area	Innate Immune System
Application	ELISA
Application Notes	Optimal dilutions should be determined experimentally by the user.
Form	Lyophilized
Storage	Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage.
Size	1 Set
Sample Type	Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates
Usage Statement	Available for Research Use Only. Not for use in therapeutic or diagnostic applications.

Target Overview
Gene Symbol	CSF3
Full Name	Colony Stimulating Factor 3
Background	This gene encodes a member of the IL-6 superfamily of cytokines. The encoded cytokine controls the production, differentiation, and function of granulocytes. Granulocytes are a type of white blood cell that are part of the innate immune response. A modified form of this protein is commonly administered to manage chemotherapy-induced neutropenia. Alternatively spliced transcript variants have been described for this gene.
Alternative Names	CSF3OS; G-CSF; GCSF
Gene ID	1440
Uniprot ID	P09919

For Research Use Only.

Human G-CSF ELISA Matched Antibody Pair Set [ABP-Q-04-122] (CAT#: ABP-Q-04-122)

Antigen Detail

Capture Antibody

Detection Antibody

General Product Property

Target Overview