Human G17 Matched Antibody Pair Set [ABP-S-1211] (CAT#: ABP-S-1211)

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Human G17 antibody pair set for ELISPOT useCapture Antibody: Mouse Monoclonal IgGDetection Antibody: Mouse Monoclonal IgG

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  • Detection Antibody Property
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Lot Number

Antigen Detail

TargetG17
DescriptionGastrin is a peptide hormone that stimulates secretion of gastric acid (HCl) by the parietal cells of the stomach and aids in gastric motility. It is released by G cells in the pyloric antrum of the stomach, duodenum, and the pancreas. Gastrin binds to cholecystokinin B receptors to stimulate the release of histamines in enterochromaffin-like cells, and it induces the insertion of K+/H+ ATPase pumps into the apical membrane of parietal cells (which in turn increases H+ release into the stomach cavity). Its release is stimulated by peptides in the lumen of the stomach.
Species ReactivityHuman

Capture Antibody

Capture ClonalityMonoclonal
Host SpeciesMouse
ImmunogenHuman Gastrin-17 peptide
CloneIV01568
IsotypeIgG
PurificationAffinity Chromatography
Buffer0.02M PBS, pH7.4,with 0.1% NaN3
ApplicationELISA

Detection Antibody

Det-ClonalityMonoclonal
Host SpeciesMouse
ConjugationUnconjugated
CloneRD1016
IsotypeIgG
PurificationAffinity Chromatography
Buffer0.02M PBS, pH7.4, containing 0.1% NaN3

General Product Property

Product OverviewHuman G17 antibody pair set for ELISPOT use
Capture Antibody: Mouse Monoclonal IgG
Detection Antibody: Mouse Monoclonal IgG
SpecificityBoth the capture and the detection antibodies in this set react with human G17.
Research AreaInflammation
ApplicationELISPOT
Application NotesOptimal dilutions should be determined experimentally by the user.
FormLiquid
StorageAvoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage.
Size1 Set
Sample TypePlasma; Serum; Cell Culture Supernatant
Usage StatementAvailable for Research Use Only. Not for use in therapeutic or diagnostic applications.

Target Overview

Gene SymbolGAST
Full NameGastrin-17
BackgroundGastrin is a peptide hormone that stimulates secretion of gastric acid (HCl) by the parietal cells of the stomach and aids in gastric motility. It is released by G cells in the pyloric antrum of the stomach, duodenum, and the pancreas.

Gastrin binds to cholecystokinin B receptors to stimulate the release of histamines in enterochromaffin-like cells, and it induces the insertion of K+/H+ ATPase pumps into the apical membrane of parietal cells (which in turn increases H+ release into the stomach cavity). Its release is stimulated by peptides in the lumen of the stomach.
Alternative NamesGAST; GAS; Gastrin
Gene ID2520 (Human); 14459 (Mouse)
Uniprot IDP01350 (Human); P48757 (Mouse)
GeneCardsGAST
HGNC4164
EnsemblEnsembl(ENSG00000184502)
OMIMOMIM(137250)
Involvement in DiseaseDiseases associated with GAST include Gastritis and Zollinger-Ellison Syndrome.
FunctionGastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
Related PathwaysIts related pathways are Secretion of Hydrochloric Acid in Parietal Cells and RET signaling.

For Research Use Only.

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