Human IL-6 antibody pair set for ELISA useCapture Antibody: mouse anti-IL-6 monoclonal antibodyDetection Antibody: mouse anti-IL-6 monoclonal antibody conjugated to HRP
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Antigen Detail | |
|---|---|
| Target | IL-6 |
| Description | Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as a phosphorylated and variably glycosylated molecule. It exerts actions through its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined as an essential role in directing the transition from innate to acquired immunity. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Mouse |
| Clone | IV01324 |
| Purification | Affinity Chromatography |
| Buffer | Prior to lyophilization: PBS, pH 7.4 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Mouse |
| Conjugation | HRP |
| Clone | RD10193 |
| Purification | Affinity Chromatography |
| Buffer | Prior to lyophilization: PBS, containing 50 % HRP-Protector |
General Product Property | |
|---|---|
| Product Overview | Human IL-6 antibody pair set for ELISA use Capture Antibody: mouse anti-IL-6 monoclonal antibody Detection Antibody: mouse anti-IL-6 monoclonal antibody conjugated to HRP |
| Specificity | Quantitative determination of Human IL-6 |
| Range | 9.38-600 pg/mL |
| Research Area | Innate Immunity |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | IL6 |
| Full Name | Interleukin 6 (IL-6) |
| Background | Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory muscle factor. In humans, it is encoded by the IL6 gene. In addition, osteoblasts secrete IL-6 to stimulate osteoclast formation. Many vascular smooth muscle cells also produce IL-6 as a proinflammatory cytokine. The role of IL-6 as an anti-inflammatory actin is mediated by its inhibitory effect on TNF-α and IL-1 and the activation of IL-1ra and IL-10. Early evidence suggests that in the context of a broader coronavirus pandemic, IL-6 can be used as an inflammatory marker of severe COVID-19 infection with a poor prognosis. |
| Alternative Names | IL6; BSF2; HGF; HSF; IFNB2; IL-6; BSF-2; CDF; IFN-beta-2; interleukin 6 |
| Gene ID | 3569(Human) |
| Uniprot ID | P05231(Human) |
For Research Use Only.
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