Mouse IL-6 antibody pair set for ELISPOT useCapture Antibody: Rat Monoclonal IgGDetection Antibody: Rat Monoclonal IgG
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Antigen Detail | |
|---|---|
| Target | IL-6 |
| Description | Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory muscle factor. In humans, it is encoded by the IL6 gene. In addition, osteoblasts secrete IL-6 to stimulate osteoclast formation. Many vascular smooth muscle cells also produce IL-6 as a proinflammatory cytokine. The role of IL-6 as an anti-inflammatory actin is mediated by its inhibitory effect on TNF-α and IL-1 and the activation of IL-1ra and IL-10. Early evidence suggests that in the context of a broader coronavirus pandemic, IL-6 can be used as an inflammatory marker of severe COVID-19 infection with a poor prognosis. |
| Species Reactivity | Mouse |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Rat |
| Clone | IV01424 |
| Isotype | IgG |
| Purification | Affinity Chromatography |
| Buffer | Preservative-free PBS, pH 7.2 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Rat |
| Conjugation | Biotin |
| Clone | RD1044 |
| Isotype | IgG |
| Purification | Affinity Chromatography |
| Buffer | PBS, pH 7.2, containing 0.09% sodium azide |
General Product Property | |
|---|---|
| Product Overview | Mouse IL-6 antibody pair set for ELISPOT use Capture Antibody: Rat Monoclonal IgG Detection Antibody: Rat Monoclonal IgG |
| Specificity | Both the capture and the detection antibodies in this set react with human interleukin-6 (IL-6). |
| Research Area | Inflammation |
| Application | ELISPOT |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Liquid |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Plasma; Serum; Cell Culture Supernatant |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | IL6 |
| Full Name | Interleukin 6 (IL-6) |
| Background | Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory muscle factor. In humans, it is encoded by the IL6 gene. In addition, osteoblasts secrete IL-6 to stimulate osteoclast formation. Many vascular smooth muscle cells also produce IL-6 as a proinflammatory cytokine. The role of IL-6 as an anti-inflammatory actin is mediated by its inhibitory effect on TNF-α and IL-1 and the activation of IL-1ra and IL-10. Early evidence suggests that in the context of a broader coronavirus pandemic, IL-6 can be used as an inflammatory marker of severe COVID-19 infection with a poor prognosis. |
| Alternative Names | IL6; BSF2; HGF; HSF; IFNB2; IL-6; BSF-2; CDF; IFN-beta-2; interleukin 6 |
| Gene ID | 3569(Human) |
| Uniprot ID | P05231(Human) |
| GeneCards | IL6 |
| HGNC | 6018 |
| Ensembl | ENSG00000136244 |
| OMIM | 147620 |
| Involvement in Disease | Diseases associated with IL6 include Kaposi Sarcoma and Rheumatoid Arthritis, Systemic Juvenile. |
| Function | Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation. |
| Related Pathways | Its related pathways are Transcriptional misregulation in cancer and Folate Metabolism. |
For Research Use Only.
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