Rat ACE2 ELISA Matched Antibody Pair Set [ABP-Q-04-18] (CAT#: ABP-Q-04-18)

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Rat ACE2 antibody pair set for ELISA use
Capture Antibody: Mouse anti-Rat ACE2 / Angiotensin-Converting Enzyme 2 monoclonal antibody
Detection Antibody: Rabbit anti-Rat ACE2 / Angiotensin-Converting Enzyme 2 monoclonal antibody conjugated to HRP

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Type Size Price Quantity  
Antibody Pair Set-Package 1 5 × 96 tests $1,120.00
Antibody Pair Set-Package 2 15 × 96 tests $2,331.43
Datasheet
MSDS
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Lot Number

Antigen Detail
TargetACE2
DescriptionAngiotensin-converting enzyme 2 (ACE2), a first homolog of ACE, regulates the renin angiotensin system (RAS) by counterbalancing ACE activity. Accumulating evidence in recent years has demonstrated a physiological and pathological role of ACE2 in the cardiovascular, renal and respiratory systems. ACE2 also has an important role in blood pressure control. This enzyme, an homolog of ACE, hydrolyzes angiotensin (Ang) I to produce Ang-(1-9), which is subsequently converted into Ang-(1-7) by a neutral endopeptidase and ACE. ACE2 releases Ang-(1-7) more efficiently than its catalysis of Ang-(1-9) by cleavage of Pro(7)-Phe(8) bound in Ang II. Thus, the major biologically active product of ACE2 is Ang-(1-7), which is considered to be a beneficial peptide of the RAS cascade in the cardiovascular system. A physiological role for ACE2 has been implicated in hypertension, cardiac function, heart function and diabetes, and as a receptor of the severe acute respiratory syndrome coronavirus. In the acute respiratory distress syndrome (ARDS), ACE, AngII, and AT1R promote the disease pathogenesis, whereas ACE2 and the AT2R protect from ARDS. Importantly, ACE2 has been identified as a key SARS-coronavirus receptor and plays a protective role in severe acute respiratory syndrome (SARS) pathogenesis. Furthermore, the recent explosion of research into the ACE2 homolog, collectrin, has revealed a new physiological function of ACE2 as an amino acid transporter, which explains the pathogenic role of gene mutations in Hartnup disorder.
Species ReactivityRat

Capture Antibody
Capture ClonalityMonoclonal
Host SpeciesMouse
CloneIV01330
PurificationAffinity Chromatography
BufferPrior to lyophilization: PBS, pH 7.4
ApplicationELISA

Detection Antibody
Det-ClonalityMonoclonal
Host SpeciesRabbit
ConjugationHRP
CloneRD1032
PurificationAffinity Chromatography
BufferPrior to lyophilization: PBS, containing 50 % HRP-Protector

General Product Property
Product OverviewRat ACE2 antibody pair set for ELISA use
Capture Antibody: Mouse anti-Rat ACE2 / Angiotensin-Converting Enzyme 2 monoclonal antibody
Detection Antibody: Rabbit anti-Rat ACE2 / Angiotensin-Converting Enzyme 2 monoclonal antibody conjugated to HRP
SpecificityQuantitative determination of Rat ACE2
Range125-8000 pg/mL
Research AreaMetalloprotease
ApplicationELISA
Application NotesOptimal dilutions should be determined experimentally by the user.
FormLyophilized
StorageAvoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage.
Size1 Set
Sample TypeSerum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates
Usage StatementAvailable for Research Use Only. Not for use in therapeutic or diagnostic applications.

Target Overview
Gene SymbolACE2
Full NameAngiotensin-converting enzyme 2
BackgroundAngiotensin-converting enzyme 2 (ACE2)[5] is an enzyme attached to the cell membranes of cells located in the lungs, arteries, heart, kidney, and intestines.[6][7] ACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II (a vasoconstrictor peptide) into angiotensin (1-7) (a vasodilator).[8][9][10] ACE2 counters the activity of the related angiotensin-converting enzyme (ACE) by reducing the amount of angiotensin-II and increasing Ang(1-7),[11] making it a promising drug target for treating cardiovascular diseases.
ACE2 also serves as the entry point into cells for some coronaviruses, including HCoV-NL63, SARS-CoV, and SARS-CoV-2.[5] The human version of the enzyme can be referred to as hACE2.
Alternative NamesACE2; ACEH; angiotensin I converting enzyme 2
Gene ID59272
Uniprot IDQ9BYF1

For Research Use Only.

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