Radioimmunoassay (RIA) has many advantages compared with other analytical methods, such as high specificity and high sensibility. Therefore, it can be used to determine all kinds of extremely trace substances with immune activity. As a trustworthy partner of in vitro diagnostics (IVD) development, Creative Biolabs provides a wide range of RIA services for our global customers. We can test tens of thousands of RIA samples every year and have accumulated abundant experience. Skilled technicians ensure that every experimental result is true and reliable to contribute to your success!

Introduction About Radioimmunoassay (RIA)

RIA is a sensitive and quantitative method that was first developed in the 1950s. This method is used to measure the concentration of the substance. It usually uses antibodies to measure antigen concentrations (such as hormone levels in the blood). Although the cost of this technique is very low, this method is extremely specific and sensitive. At present, it has been widely used in IVD area.

Radioimmunoassay.Fig.1 Radioimmunoassay. (Grange, 2014)

RIA for Hormone Levels Detection

Thyrotropin (TSH) is a glycoprotein produced in the anterior pituitary gland. The TSH acts on receptors of the thyroid gland to promote the synthesis and release of thyroid hormones. The thyroid hormone plays an important role in the growth and development of humans and animals. Therefore, it is necessary to detect the level of this hormone and assess the function of the thyroid. RIA is considered the gold standard method to determine thyroid hormone levels because RIA exhibits high sensitivity and specificity and low detection limits. In humans, RIA of TSH is routinely performed to assess hyperthyroidism and hypothyroidism. In dogs, TSH is assayed by competitive RIA to diagnose hypothyroidism. Equine hypothyroidism can also be diagnosed by RIA-TSH.

Radioimmunoassay dose-response curves of total T4 concentrations using the sodium salicylate method to separate binding proteins from serum.Fig.2 Radioimmunoassay dose-response curves of total T4 concentrations using the sodium salicylate method to separate binding proteins from serum. (Tangyuenyong, 2017)

Our Services

  • Virus Antigen Assays
  • Bacterial Antigen Assays
  • Parasite Antigen Assays
  • Drug Binding Assays
  • Receptor Binding Assays
  • DNA and RNA Assays
  • Cell-Based Bioassays
  • Protein Characterization and Protein Quantitation Assays
  • Highly Specific Measurements of Both Small Molecule and Biological Drugs

Why Us?

  • Professional: our scientists are committed to the immunology field for many years and they are very familiar with the relevant detection technology.
  • Quality & Witness: our experts will communicate with you to understand your needs and give you professional solutions. We have served thousands of international customers and they are satisfied with our service. Therefore, we are the most reliable choice for customers.
  • Efficient & Low cost: our scientists have outstanding professional skills and abundant experience to help our customers reduce cost and turnaround time.

Creative Biolabs has the first-class capability to provide a full range of RIA services for customers in the IVD research field. With advanced research strength, we will develop the best solutions to provide fast, accurate and reliable services. If you are interested in our services, you can contact us.


  1. Grange, R. D.; et al. Radioimmunoassay, enzyme and non-enzyme-based immunoassays. BJA: The British Journal of Anaesthesia. 2014.
  2. Tangyuenyong, S.; et al. Sensitive radioimmunoassay of total thyroxine (T4) in horses using a simple extraction method. Journal of Veterinary Medical Science. 2017, 79(7): 1294-1300.

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