Biomarkers are commonly used to characterize drug sensitivity, disease status, and physiological status monitoring. Biomarker assays provide an important reference for the prevention, treatment, and prognosis of harmful biological effects, not only for individual health monitoring, but also for group health assessment.
Creative Biolabs offers the highest quality bioanalyses in a variety of matrices for use in preclinical settings as well as small and large scale epidemiological studies. With our state-of-the-art technology, we have developed a rich inventory of bioanalytical assays spanning a wide range of application areas. Our methods have been used in numerous research projects, and new analytical methods are developed continuously for our customers.
Background
The gene encoding alpha-1 antitrypsin (AAT) is SERPINA1 which consists of seven exons and six introns. After translation, transcription, and post-translational modifications (PTMs), SERPINA1 is released into the circulation. As a known genetic cause of chronic obstructive pulmonary disease (COPD), alpha1-antitrypsin deficiency (AATD), SERPINA1 had the possibility to be used as a biomarker to provide diagnostic and prognostic information.
Fig.1 Structure of SERPINA1.1
Diagnostic Power
As an endogenous anti-inflammatory protein, SERPINA1 has its own advantages over other immunotherapy candidates. SERPINA1 is an acute phase reactant secreted mainly by hepatocytes during inflammation. Its dominant function is to inhibit elastase released by neutrophils. Besides, SERPINA1 counteracts the effects of inflammatory mediators, exhibits anti-inflammatory as well as immunomodulatory effects that can be independent of protease inhibition. Many anti-inflammatory agents would inhibit appropriate immune response, while SERPINA1 does not.
Increase Your Chance for Paramount Discoveries
Creative Biolabs provides biomarker assays covering from basic protein quantitation to customized assay development to support your academic disease research and drug development, or to develop and validate assays to suit your specific requirements.
| Cat | Service |
| BAS68-1 | Protein Quantitation Service |
| BAS68-2 | SERPINA1 Expression Analysis Service |
| BAS68-3 | Mass Spectrometry-based Assay |
| BAS68-4 | SERPINA1 Variants Identification Service |
| BAS68-5 | Functionally Active SERPINA1 Measurement |
1. Protein Quantitation Service
SERPINA1 is a serine protease inhibitor found in a variety of biological fluids. Creative Biolabs provides quantitative measurement services of SERPINA1 protein in different kind of samples.
- ELISA
- Nephelometry
2. SERPINA1 Expression Analysis Service
To study the association between SERPINA1 and specific disease such as HBV or HBV-related HCC, Creative Biolabs provides monoclonal and polyclonal antibody development services against SERPINA1 and performed subsequent exams such as WB and IHC.
3. Mass Spectrometry-based Assay
For instance, using SELDI-TOF-mass spectrometry, scientists analyzed protein expression patterns from plasma and identified a cleaved peptide of SERPINA1 (CAAP48) as potential sepsis biomarker.
4. SERPINA1 Variants Identification Service
5. Functionally Active SERPINA1 Measurement
If you are looking for SERPINA1 analyzing services, Please don't hesitate to contact us today to develop custom solution for specific needs. We will work to accommodate your request.
Reference
- From Wikipedia: By Thomas Shafee - Own work, CC BY 4.0, https://commons.wikimedia.org/wiki/File:Alpha_1-antitrypsin.png
For Research Use Only.
