Alpha-1 antitrypsin (AAT), also known as SERPINA1, is a kind of protease inhibitor that protects tissues from inflammatory cell enzymes, especially neutrophil elastase. Creative Biolabs provides far-ranging AAT protein analysis services. Our professional R & D team and complete technical platform can meet your various needs for SERPINA1 Analysis and inject a powerful boost to your research projects.
Scientific Validity
AAT is encoded by the human SERPINA1 gene and can inhibit a variety of proteases to prevent tissues from being damaged by binding to them covalently. AAT is mainly produced in the liver and travels in the bloodstream to the lungs, where it protects them from damage caused by infection-fighting agents and irritants. Hence, alpha-1-antitrypsin deficiency (AATD) is an inherited disorder caused by the mutation in the corresponding coding gene and the severity of AATD mainly depends on the condition of the two inherited genes. In general, people who get AATD have low levels of AAT in their bloodstream, which leads to a higher risk of developing lung and liver diseases. In addition, recent research has shown that people with severe AATD deficiencies also have a greater chance of developing liver cancer and non-liver cancers.
AAT: A blood biomarker of AATD
The most common type of AATD is the ZZ type, in which the AAT proteins are misshapen. These proteins cannot enter the bloodstream, resulting in lower levels of ATT in the blood. The low level of AAT in the bloodstream cannot meet the need of the lungs and other organs to fight infection, leading to a chronic obstructive pulmonary disorder such as emphysema and bronchitis. The accumulation of AAT in the liver will also damage liver cells and increase the risk of hepatopathy. Hence, the levels of AAT in the blood can be used as an effective marker for AATD diagnosis.
As shown in Fig.1, there are four main kinds of AAT tests that can be used to assess the levels of the AAT protein in the blood and find inherited genetic variants that contribute to AATD. The technology platform and purpose of each detection method are different, and each method can be selected to fit the different needs of researchers.
Fig.1 Four different modes of analysis targeting AAT.
Services at Creative Biolabs
Creative Biolabs provides a top-ranking and comprehensive analysis service for ATT identification and quantification. With the addition of plenty of excellent researchers and the investment of funds, Creative Biolabs has established many analytical platforms such as an immunoassay platform, DNA sequencing platform, and PCR platform, to meet the needs of different customer groups. This results in an assay that is simultaneously familiar and cutting edge and enables the use of lower sample volumes while also providing more sensitivity. Undoubtedly, these platforms allow us to implement the following high-level SERPINA1 Analysis.
- AAT blood level test
- AAT phenotype test
- AAT genotyping
- AAT DNA sequence
With excellent research teams and diverse technology platforms, Creative Biolabs is the best choice for your experimental research and drug development. We also provide customized analysis services for a variety of targets to meet your various research needs.
If you have any requirements for AAT protein analysis, please do not hesitate to contact us for more information.
For Research Use Only.
