Vascular cell adhesion molecule-1 (VCAM1) is regarded as a biomarker that reflects renal disease activity and treatment response. Armed with comprehensive biotechnique and advanced platform, Creative Biolabs offers custom VCAM1 analysis services for worldwide clients.
Background
VCAM1, also known as CD106, is an integrin and Ig superfamily group member that is induced on endothelial cells in response to numerous inflammatory cytokines such as TNF, IL1, and bind integrin partners on leukocytes. VCAM1 is a transmembrane type 1 protein expressed in several species and has different conformations. As Fig.1 shown, VCAM1 contains an extracellular N-terminal portion, with a variable Ig-like domain produced by splice variants of the VCAM1 gene. There are two isoforms of human VCAM1: one with 7 Ig-like domains (full length) and one with 6 Ig-like domains (with excision of domain 4).
Fig.1 Molecular structure of VCAM1 in human.1
Scientific Validity
VCAM1 expression, together with soluble VCAM1 (sVCAM1) induced by the shedding of VCAM1 by ADAM metallopeptidase domain 17 (ADAM17) have been proposed as biomarkers in various disease such as cardiovascular disease, immunological diseases, cancer and autoimmune myocarditis. The protein is cleaved near the transmembrane site. Several studies have shown elevated and strongly correlated serum and urinary VCAM1 levels with lupus nephritis activity and severity.
Services at Creative Biolabs
There is an increasing number of molecular imaging probes developed for non-invasive monitoring of atherosclerosis. VCAM1 is a promising target to detect early and advanced atherosclerotic lesions, which are easily accessible to blood contrast agents due to their localization on the endothelial surface. For several years, there has been an increase in molecular imaging methods for detecting VCAM1 in PET, SPECT, MRI, optical imaging and ultrasound.
Besides, Creative Biolabs also takes full use of microparticles, immunoliposomes, peptides, nanobodies to develop novel VCAM1-targeted imaging systems. VCAM1 specific antibody or antibody pair at Creative Biolabs is also available for assay development.
- VCAM1 expression level analysis
- VCAM1 imaging-Enables researchers to detect atherosclerotic plaques and evaluate a new therapy in animal studies.
- VCAM1 Binding Peptides Screening
- VCAM1 ELISA Assay
- VCAM1 isoform analysis
If you are interested in our analysis services, please feel free to contact us for more information.
Reference
- From Wikipedia: By Emw - Own work, CC BY-SA 3.0, https://commons.wikimedia.org/wiki/File:Protein_VCAM1_PDB_1ij9.png
For Research Use Only.
