Virtual tissue/organ/system (virtual patient) is a revolutionary system modeling tool for biomarker candidate identification and disease diagnosis. With our unique modeling algorithm, Creative Biolabs provides virtual patient modeling services, offering a gateway to the complex molecular processes occurring within each of our cells, fostering insight and discovery for academic use. The key of our virtual patient modeling is that a new algorithm enables computers to diagnose a disease with unprecedented accuracy, renewing predictions.
The model has been built on the premise that the onset and progression of disease are associated with a malfunction in the complex biological networks occurring in specific cells or tissues in our bodies. The model is essentially a computational representation of the complex molecular networks in cell types and tissues. All the different biological entities such as genes and proteins are represented as objects within the model, which when taken together carry out all the cellular processes which keep us healthy or, if altered, contribute to the development of diseases. With virtual tissues, the modeling begins by feeding anatomical data drawn from noninvasive high-resolution imaging of an individual's actual organ into a complex mathematical model of the mechanisms that govern that organ's function. Algorithms running on powerful computers resolve the resulting equations and unknowns, generating a virtual organ that looks and behaves like the real thing.
Fig.1 The modular architecture of virtual tissues. (Shah, 2010)
A major focus in the development of virtual tissues is oncology with the integration of information on a range of cancer-associated signal transduction pathways, consequences of mutations, and mechanistic drug effects that are used to generate virtual tumor models. The generic models become specifically tuned to specific cancer subtypes. Creative Biolabs offers biomarker identification services for global clients. The combination of model predictions and molecular profiling data enables the identification of biomarker sets.
Virtual patient consists of molecular models of key tissues likely to affect cellular response to a specific therapy, including the liver, to indicate activation or deactivation of drugs, healthy tissue types, to evaluate side effects, and, ideally, the immune system, to reflect responses to immunotherapies. In vitro models offer a high-throughput approach for assaying chemical-induced molecular and cellular changes. Technological advances in multiresolution imaging and multiscale simulation are making it feasible to reconstruct tissues in silico. In toxicology, these virtual tissues or organs could be used to predict histopathological outcomes from alterations of cellular phenotypes that are controlled by chemical-induced perturbations in molecular pathways.
Although our core services are currently focused on IVD, our technologies have a broad range of applications and can be translated to other areas such as drug development, vaccines test, and personalized precision medicine. Creative Biolabs is increasingly active in research areas outside of IVD and would be happy to discuss your project needs. If you are interested in our services, please feel free to contact us for more information.
For Research Use Only.