Creative Biolabs has been a long-term expert in the field of antibacterial and antifungal drug discovery. Based on our extensive experience and world-leading technology platforms, Creative Biolabs provides a series of antibiotic resistance test services for our clients all over the world.
Antibiotic resistance can be achieved through different channels, such as the horizontal acquisition of resistance genes, recombination of foreign DNA into the chromosome, or mutations in different chromosomal loci. Mutation rates generally include selectively favorable, unfavorable, or neutral mutations. Under the concept of antibiotic resistance, the mutation rate is usually represented as the in vitro frequency at which detectable mutants appear in the bacterial population after a given antibiotic concentration. And only selective favorable mutations that lead to a visible antibiotic resistance phenotype will be recorded. In this case, the low mutation rate is considered an advantage of the antibiotic.
However, as mutations in different genes can produce similar antibiotic resistance phenotypes, the assessment of mutation rates becomes more difficult. What’s more, the ability of some physiological conditions to modulate bacterial mutation rates and the ability of some antibiotics to increase mutagenicity also severely limits the possibility of predicting "true" mutation rates.
Fig.1 Patchwork structure of bacterial populations selected at different antibiotic concentrations. (Martinez, 2000)
Studies have shown that antibiotic resistance follows two patterns, including a single mutation that provides a large resistance benefit and multiple mutations that the combination of small benefits for each mutation yields high levels of resistance. Creative Biolabs provides a series of resistance studies that help predict the frequency of emergence of resistant mutants after exposure to antimicrobial agents, as well as the types of drug-resistant strains that are likely to emerge or emerge clinically. The services including but not limited to:
Equipped with world-leading technology platforms and professional scientific staff, we are pleased to offer the most qualified services and products for antibacterial and antifungal drug discovery. If you are interested in our products or services, please do not hesitate to contact us for more detailed information.
Reference
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