Creative Biolabs is proud to provide world-leading benign prostatic hyperplasia (BPH) non-human primates (NHPs) models for our global customers. All urogenital disease models presented by our company exhibit distinct features and etiology of human urogenital diseases. With these well-established model animals and our highly professional team of experts, we sincerely look forward to working with worldwide researchers and assisting their valued drug development projects.

What is benign prostatic hyperplasia (BPH)?

Benign prostatic hyperplasia (BPH) is a common prostatic disorder involves non-cancerous hyperplasia of the prostate. It often occurs in middle-aged men. BPH is mainly characterized by an increase in the number of prostatic stromal and epithelial cells, resulting in the formation of large, fairly discrete nodules in the periurethral region of the prostate. The nodules will push on and narrow the urethra once large enough, which causes increasing resistance to flow of urine. This will in turn press the bladder to work harder and may lead to hypertrophy, weakness, or instability of the bladder muscle.

The advantages of non-human primates (NHPs) models

Non-human primates (NHPs) resemble humans with many similarities in terms of physiology, anatomy, neurology, as well as immunology, all of which make them ideal models for biomedical research. NHPs may be the best research model to study human BPH due to their similar prostate to that of human beings.

Benign Prostatic Hyperplasia (BPH) Model

BPH models provided by Creative Biolabs

Naturally occurring animal models for human BPH offer advantages over other models but this is limited to an only few species. Except for human beings, spontaneous BPH is only found in dogs and chimpanzees. Spontaneous BPH chimpanzee may be the best research model to study human BPH since they are the closest species to human beings. However, the limited availability of the chimpanzees for studying BPH makes this model less practicable.

Our company provides the BPH model induced by androgen which is more readily available and much cheaper than spontaneous BPH chimpanzee model. Different proliferative phases of BPH model can be obtained using this method. A full set of strict endpoint QC measures will also be performed to characterize the disease levels, including:

  • Maximum flow rate
  • Average flow rate
  • Post-voiding residual (PVR)
  • Maximum urinary flow volume
  • Intra-bladder pressure
  • Urination rate
  • Prostate weight
  • Prostate stiffness

Creative Biolabs is confident in tailoring the most appropriate models to meet our customers' specific requirements. Alternative systematic disease models are also available, e.g. neurological disease, renal disease, cardiovascular and metabolic disorders, liver disease, and immune disease. Please feel free to contact us for further discussions.

For Research Use Only.

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