Creative Biolabs provides site-specific rodent bone defect models for studying the effects of bone substitutes, biologics or cell-based products on bone regeneration. These models cover long bone defect models, calvarial bone defect models, and maxillofacial bone defect models.
Bone Healing Capacity
In general, bone possesses a good healing capacity and the vast majority of bone defects, when stimulated by well-balanced biological and micro-environmental conditions, heal spontaneously. However, this capability may be limited/insufficient under certain clinical situations such as large bone defects after high energy trauma, revision surgeries, or tumor resection. As a consequence, the development of innovative therapies for bone regeneration is focused. The effect of these treatments is often evaluated using animal models due to their standardized production of defects, low cost, reproducible results, manageability during an experiment, and minimal ethical/societal implications.
Rodent Models of Bone Defects
Despite the fact that no animal model accurately reproduces the human bone physiology, biology, structure and biomechanics, small and large animal models have been developed to study the effects of bone substitutes, scaffold, biologics or cell-based products on bone regeneration. Rodent models have been used extensively used and have contributed greatly to translational research. Usually, advanced site-specific bone defect rodent models are preferred by investigators, which are so-called critical size defects.
Induction of Critical Size Defect Models
A critical size-defect (CSD) is defined as the smallest type of intraosseous wound that does not heal spontaneously by bone formation during the subject's lifetime. The CSD model creates an environment where fracture healing is impeded due to lack of blood flow to the fracture site or lack of proper fixation, or both. This allows researchers to study various pathways involved in fracture healing and various therapies to augment healing. CSD models have been described for small and large animals. The latter is advantageous regarding the dimensions and biomechanical situation but are time, labor, and cost-intensive and the former are more suitable for basic research questions and screening experiments.
Fig.1 Schematic of rat cranial bone defects.
(Zhang et al. 2014)Creative Biolabs is capable of providing in vivo preclinical services using the most extensively used rodent CSD models listed as follows:
A wide range of assessments can be performed such as:
Additionally, other examples of rodent musculoskeletal disease models that you may be interested include:
At Creative Biolabs, a team of experienced musculoskeletal experts will be assigned to provide our clients with the best-quality preclinical laboratory services for evaluation of both orthopedic products and compounds. If you're interested in our services, contact us for more information and a formal quote.
Reference
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