Creative Biolabs can help you screen and validate potential targets by using several gene manipulation methods related to genome editing and gene silencing. Genome editing, also known as gene editing, is the insertion, deletion or replacement of DNA at a specific site in the genome of an organism or cell. Gene silencing refers to prevent the expression of a certain gene. Both of these two approaches have been effectively used in a wide variety of tissues and organisms to study how genome influences phenotype.

Gene Manipulation for Fungi

Creative Biolabs offers a range of gene manipulation solutions to cater to your needs. We perform complete toolset comprising trusted solutions for every step of gene manipulation. The optimized, validated technology systems are designed to minimize and eliminate the trial-and-error phase and help you get answers faster with fewer errors.

Types of our gene manipulation techniques including but not limited to:

Gene Knockout

Gene knockout is a genetic technique that results in one or several inactivated genes by altering the gene sequences. Gene knockout is also the term that refers to the gene that is knocked out or the organism that carries the gene knockout. Knockout organisms are used to study gene function, usually by investigating the loss of function of a gene. By comparing the differences between the knockout organism and normal individuals, inferences of how the gene function can be drawn. With over decades of experience and the state-of-the-art drug discovery platforms, we can totally meet your project requirements and budgets in the gene knockout services.

Gene Overexpression

Gene overexpression technique provides a powerful alternative tool to infer gene functions that remain to be discovered by gene knockout analysis or not yet possible creating targeted deletions. The rapidly growing gene expression databases and improvement in bioinformatics tools shed the light on the new strategies to discover therapeutic targets. More recently, strategies that successfully applied overexpression in additional ways emerged, expanding the overexpression repertoire.

Gene Silencing

Human genome project has shed the light on understanding the human gene functions. Of the roughly 35,000 genes in the human genome, only a few have been identified as known genes. Therefore, validating and verifying a positive lead is the key to effective drug development. Developing a drug against a specific target is an extensive commitment in terms of time and money. Target validation is a crucial step in the drug discovery pipeline. For years, Creative Biolabs has been developing techniques and providing services for drug discovery and target validation by the means of gene silencing.

Gene Conditional Expression

Our creative functional genomics approach tailor-made for diploid organism allows the conditional knockout of genes. This innovative approach is used through a combination of target gene replacement of one allele and conditional gene expression of the other. Our platform demonstrates both the reproducibility and reliability for determining gene essentiality, and it is extremely suitable for systematic and large-scale essential gene identification and validation in diploid pathogenic microorganisms.

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