Investigations of human cell and tissue function have usually been limited to ex vivo analyses, non-invasive procedures, or clinical trials that are costly and severely limited due to ethical constraints. Small animal models, especially mice, which equipped with human cell and tissue would overcome these limitations. Creative Biolabs has constructed and validated a broad range of humanized mouse models that are commonly used for the sake of in vivo investigation of pathogenesis and function, as well as treatment evaluation.

Humanized Mouse Models

Humanized Mouse Models

Animal models have been used as surrogates of human biology due to the logistical and ethical restrictions of working with cell and tissue samples from human donors. Small animals, especially mice, are widely used mammalian model systems due to their small size, ease of maintenance and handling, a short reproductive cycle, sharing of genomic and physiological properties with humans and ability to be easily manipulated genetically.

Although numerous basic biology has been obtained from mouse studies, there are limitations to mouse models when investigating human biology. Several components of mouse biological systems are inconsistent with those of humans, particularly their immune system. The property and pathogenesis of immune responses reacted to pathogens that can only infect human cells may be distinctly different from those of murine infectious agents or murine-adapted human infectious agents. In addition, many drugs and human pathogens are species-specific. The nature and pathogenesis of immune responses mounted against pathogens that can infect only human cells may distinctly differ from that of murine infectious agents or human infectious agents that have been murine-adapted.

Currently, humanized mice have begun to fill this gap and have become important pre-clinical tools for biomedical research. Since immunodeficient mice undergoing mutations in the IL2 receptor common gamma chain (IL2rgnull) have already been described in the early 21st century, researchers have been capable to engraft murine recipients with human hematopoietic stem cells that can develop functional human immune system in mice. Eventually, the application of humanized mice may ensure implementation of truly “personalized” medicine in the clinic.

Application

The engrafted functional human immune systems, including functional T and B cells after engrafting human hematopoietic stem cells (HSC) in the body, have the ability in T / B cell-dependent immune responses, anti-viral responses, antibody production, and allograft rejection. With the development of genetic manipulation, humanized mouse models contribute to ensuring the considerable progress of research in oncology, human infectious disease, allergies, regenerative medicine, graft versus host disease and immunity. Moreover, human-specific infectious agents for which animal models were previously unavailable can be investigated in vivo using these new humanized mouse models.

With years of experience in the field of animal model, Creative Biolabs offers various humanized mouse models, including a broad range of immune checkpoint knock-in mouse models and also some other models of your choice:

If you are interested in learning more about Creative Biolabs' animal models or drug discovery service, please contact us for more details.

For Research Use Only.



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