As a reliable and trusted contract research organization, Creative Biolabs is specialized in providing custom services to both academia and biotech/pharmaceutical industries in the field of antibody discovery. We use validated in vitro plaque reduction neutralization assay and systematic analysis to shorten your development time with greater confidence.
In the development of antiviral antibodies, viral neutralization activity is an important consideration to evaluate the potential of candidate antibodies to neutralize the target virus.
Plaque reduction neutralization assay (PRNT) is a vital method used to measure the ability of antibodies to neutralize cells infected with virus particles. It is considered to be the most virus-specific serological test currently and is widely used in research.
Commonly, infectious virus particles multiply in cells, forming circular areas of the infected regions, known as plaques. In vitro plaque reduction assay evaluates the neutralization ability of antibody samples by measuring the plaque forming efficiency of a virus in the presence of antibody samples at different concentrations.
Fig. 1 Diagram of plaque reduction neutralization assay.1
Relying on the expertise of senior scientists and best-in-class equipment, Creative Biolabs offers a variety of research services to support proof of concept, down-selection screening, and activity/target validation. We are devoted to providing custom in vitro plaque reduction neutralization assay in several key virus families, and selecting the appropriate assays for your specific compound and mechanism of action.
Currently, we can provide the in vitro plaque reduction neutralization assays covering the following virus types including but not limited to:
| Dengue virus serotype 1/2/3 (DENV) | Influenza A H1N1 | Respiratory Syncytial Virus (RSV) |
| Pseudotyped VSV-SARS-CoV-2 | Influenza A H3N2 | Herpes Simplex Virus-1/2 |
| Venezuelan Equine Encephalitic virus (VEEV) | Influenza B | Chikungunya (CHIKV) |
| Human Cytomegalovirus (hCMV) | Zika Virus (ZIKV) |
Scientists in Creative Biolabs are pleased to leverage our expertise and technologies to assist our clients with their cutting-edge projects. Currently, we offer a full range of neutralization assays to characterize antiviral antibodies’ activities. We are willing to bring together years of valuable experience and research to assist clients with their projects.
For more detailed information, please feel free to contact us or directly send us an inquiry.
Reference
For Research Use Only.
