As a reliable partner of the top global pharma companies and research agencies, Creative Biolabs brings together the market-leading in vivo PK (pharmacokinetic) expertise to build our in vivo PK service team. We are recognized as the world leader for providing the largest and most diverse portfolio of standard and custom professional in vivo PK studies. Now, we provide all aspects of in vivo PK support including the planning of studies and the analysis of required samples, and can offer them as part of a complete development program, a full-service single-study package or a stand-alone service, which can be strictly in compliance with GLP regulations.
The Importance of in vivo PK Studies
Pharmacokinetics (PK) dedicated to determining the mechanisms of a drug's absorption, biodistribution, when it eliminated from the body and what it becomes. It is a study of how an organism affects a drug. In vivo PK studies are critical to ensure drug candidates have appropriate PK properties that can be evaluated in preclinical pharmacology and safety studies. In vivo PK studies provide required and useful information that indicates human equivalent doses (HED), no effect levels (NOEL), and pharmacokinetic/pharmacodynamic (PK/PD) drivers. Conducting PK studies also allows the determination of PK parameters such as AUC, clearance, half-life, volume of distribution, Cmax, and Cmin.
We can conduct in vivo PK studies in various animal species, including:
The iterative nature of in vivo PK screening calls for rapid cycle times with changing priorities. To meet the challenging requirements, Creative Biolabs has built a team of experienced scientists with facilities and processes designed specifically to provide the best strategy and protocols customized to suit any drug discovery program. Our capabilities include:
Why Choose Us
These in vivo PK approaches above can be integrated within discovery research, which enable incredible flexibility and are extremely efficient in supporting the diverse needs and increasing demand for in vivo profiling. All data generated will be shared in a summary spreadsheet that includes calculated PK parameters where required. In vivo PK studies in Creative Biolabs can be exploratory or more extensive and formalized requiring GLP compliance. With thoroughly understanding the DMPK of a potential clinical candidate, we can assist you in the early drug development program. If you have any special needs in method development for in vivo PK studies or be interested in learning more about Creative Biolabs' method validation services, please contact us for expert support.
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