Intrauterine Growth Retardation (IUGR)-Diabetic Model

Creative Biolabs offers a wide range of IUGR models for later diabetes studies, including nutritional models, chemically induced models and surgery models.

Intrauterine Growth Retardation (IUGR) Models

Fig.1 Intrauterine programming of type 2 diabetes.
(M.S et al. 2007)

Intrauterine growth retardation is a common complication of pregnancy and a significant cause of perinatal morbidity and mortality. As a common cause of IUGR, uteroplacental insufficiency limits the availability of substrates, growth factors, and hormones to the fetus and retards growth during gestation. Therefore, diseases could be induced in adulthood due to this adverse intrauterine environment in which a fetus grows and develops, including obesity, hypertension and type 2 diabetes. There have been reports showing that this abnormal metabolic intrauterine milieu affects the development of the fetus by modifying the gene expression and function of susceptible cells in the pancreas, muscle, and liver. However, the underlying cellular and molecular mechanisms remain to be deeply elucidated.

IUGR has been associated with the later development of diseases in adulthood such as type 2 diabetes. To study the molecular basis of the relationship between IUGR and the development of type 2 diabetes in later life, various rodent models have been developed, including nutritional models of IUGR, experimentally induced models and induction of uteroplacental insufficiency.

Commonly Used Models of IUGR

The most common rodent nutritional models used for inducing IUGR to study the development of Type 2 diabetes are models that employ protein calorie restriction, total calorie restriction, and glucocorticoid exposure. In a low protein model, experimental groups are fed a diet containing less protein, resulting in fetal growth restriction and a higher risk of diabetes. In a maternal glucocorticoid exposure model, excessive glucocorticoid exposure in late pregnancy predisposes the offspring to glucose intolerance and insulin resistance.

Bilateral Uterine Artery Ligation

In rats, intrauterine growth retardation can be induced by bilateral uterine artery ligation. In this model, blood flow to the fetus is reduced to a similar degree to that observed in human pregnancies resulting from uteroplacental insufficiency. Subsequently, adult rats develop pathological features of diabetes, such as defects in insulin secretion, insulin resistance, and pancreatic β-cell loss, which are main features of type 2 diabetes in humans.

Creative Biolabs provides assessments for testing the effectiveness of potential drugs depending on your research objectives, including but not limited to:

• Body Weight
• Metabolic Parameters
• Glucose and Insulin Levels
• Glucose Tolerance Testing
• Insulin Tolerance Testing
• Immunohistochemistry

Additionally, Creative Biolabs also offers other types of rodent metabolic disease models that you may be interested in:

• Streptozotocin (STZ)-Induced Diabetic Model
• Streptozotocin-Nicotinamide-Induced Diabetic Model
• Alloxan-Induced Diabetic Model
• High-Fat Diet/STZ Induced Diabetic Model
• Cafeteria Diet-Induced Obesity
• High Fat Diet-Induced Obesity Model
• Monosodium Glutamate (MSG)-Induced Obesity Model
• Nutritional Models of NAFLD/NASH
• Partial Pancreatectomy Diabetic Model

Creative Biolabs offers a broad range of animal models to our worldwide customers. We are also flexible enough to tailor specific protocol to meet novel projects' demands. If you do not see the model you are interested in, please feel free to contact us, we'll be in touch within 24 hours to let you know if it is feasible.

Reference

1. M.S, Martin-Gronert.; S.E, Ozanne. Experimental IUGR and later diabetes[J]. Journal of internal medicine. 2007, 261(5):437-52.

For Research Use Only.