Creative Biolabs is able to provide various metabolic disease models, including genetic, nutritional, chemically-induced, and the most comprehensive relevant services with professional expertise.
As a potential risk for diseases like hypertension, stroke and type 2 diabetes, currently, the prevalence of obesity is rising to epidemic proportions. Among the diverse animal models for obesity, polygenic models are frequently used, including a chemically induced model, which is monosodium glutamate (MSG)-induced obesity model.
Characteristics of MSG Induced Obesity Models
MSG is the sodium salt of glutamic acid and is frequently used as a food seasoning. Studies about injecting MSG into neonatal experimental animals began in the 1970s. Now it is widely known that adult mice and rats treated neonatally with MSG will trigger the development of obesity coupled with several other endocrine and metabolic abnormalities.
In mice, administration of MSG to newborn mice has been shown to result in a selective destruction of brain arcuate nucleus neurons projecting to the ventromedial hypothalamus and paraventricular nucleus, resulting in a syndrome of obesity, stunting, and infertility. Mice with MSG-induced lesions are hyperphagic and develop obesity with ensuing insulin resistance and hyperinsulinemia.
Fig.1 Effects of bezafibrate on glucose tolerance test in male MSG mice at 7 weeks after treatment. (Sasaki et al. 2011)
Similarly, in rats, neonatal MSG administration will lead to the selective destruction of neurons in the hypothalamus, including ventromedial and arcuate nuclei (ARC). The neuronal loss impairs insulin and leptin signaling and impacts energy balance as well as pituitary and adrenal activity. In contrast to other models of obesity, MSG-treated rats are characterized by hyperinsulinemia, normoglycemia, elevated basal corticosterone level as well as increased lipogenesis and reduced lipolysis in the adipose tissue, despite their normophagia. Besides, MSG-treated rats show unchanged or decreased body weight in comparison to control animals.
As the leading services provider for obesity mechanism study and anti-obesity drug development, Creative Biolabs is capable of offering various assessments including but not limited to:
Additionally, Creative Biolabs also offers other types of rodent metabolic disease models that you may be interested in:
If you are interested in our monosodium glutamate (MSG)-induced obesity model, please do not hesitate to contact us or send us an inquiry. We are willing to share our state-of-the-art platforms and sufficient expertise to assist your research.
Reference
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