Creative Biolabs has spent decades of efforts to optimize and bring specialized non-human primate (NHP) neurological models to our global customers. We have unparalleled platforms and rich experience to guarantee cost-effective service. We warmly welcome our customers to consult and negotiate their cutting-edge projects with us.

What is a nervous system?

Generally speaking, the nervous system consists of brain, spinal cord, and nerves. The whole body responses and functions are controlled by the nervous system. Disorder or dysfunction within any part of the nervous system may lead to difficulties in swallowing, breathing, speaking, moving, learning, etc.

Typical symptoms of neurological disease

A neurological disease can be described as any disorder within the nervous system. It consists of series of symptoms caused by structural, biochemical or electrical abnormalities in the brain, spinal cord or other nerves.The characterized symptoms include partial or complete paralysis, muscle weakness, partial or complete loss of sensation, seizures, poor cognitive abilities and unexplained pain, etc.

Neurological Disease Models

The important role of non-human primates (NHPs) models in neurological disease

Non-human primates (NHPs) are widely used for studying human brain function and neurological diseases. For example, research on NHPs has made a great contribution to our knowledge of Alzheimer's disease. Due to the previous studies, the effective proposed treatments have been developed. Such models also play vital importance in developing dopamine agonists and deep brain stimulation which have proved to be available treatments of Parkinson's disease. Different forms of affective disorders including Tourette syndrome, major depression, and anxiety disorders are now being treated using deep-brain stimulation based on the pioneered work on NHPs.

Typical neurological disease models provided by Creative Biolabs

Parkinson's Disease (PD) Model

Parkinson's disease (PD) is a debilitating neurodegenerative disease characterized by shaking, rigidity, slow movement, and walking difficulty. Our team provides two widely used PD models: 6-OHDA and MPTP-induced PD models. Three major testing items are provided to assist the research including general measures, behavioral tests, and functional imaging.

Middle Cerebral Artery Occlusion (MCAO) Model

Middle cerebral artery occlusion (MCAO) is a standard animal model of focal cerebral ischemia. Occlusion of the middle cerebral artery results in some defects: sensory loss of the contralateral face and arm, contralateral neglect syndrome, aphasia, paralysis or weakness of the contralateral face and arm, etc. We build MCAO models using microneurosurgery technique. Follow-up tests include physiological parameter, a standard neurological deficit score, MRI imaging.

Spinal Cord Injury (SCI) Model

A spinal cord injury (SCI) is damage to the spinal cord that alters its function temporarily or permanently. SCI models can be classified into 6 categories including compression, contusion, distraction, transection, dislocation and chemical models. Creative Biolabs is capable of providing different kinds of SCI based on clients' needs. Furthermore, we can provide multiple assessments including motor-evoked potential (MEP), somatosensory-evoked potential (SSEP), MR imaging, and monkey hindlimb score (MHS), etc.

Neurological Disease Models

Cerebral Infarction Model

A cerebral infarction is a necrotic area in the brain caused by a narrowing or blockage of the arteries that supply blood and oxygen to the brain. We build cerebral infarction models based on the advanced microneurosurgery technique. Endpoint measurements include physiological parameters, a standard neurological deficit score, and MRI imaging.

Cerebral Stroke Model

A stroke is cell death caused by poor blood supply to the brain. It will result in part of the brain not functioning properly. Microneurosurgery technique is adopted to build cerebral stroke models. A full set of tests will be provided including physiological parameters, a standard neurological deficit score, and MRI imaging.

Creative Biolabs provides alternative neurological disease models for worldwide clients. Novel/unique disease models can also be established upon specific custom requests. Our scientists are glad to leverage their extensive expertise in NHP studies to benefit worldwide clients. Please feel free to contact us for further discussions.

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