Creative Biolabs is an expert in providing the super-class non-alcoholic steatohepatitis (NASH) non-human primates (NHPs) models. All liver disease models provided by our team exhibit distinct features and etiology of human liver diseases, which have been proved highly effective in evaluating the efficacy of lead compounds and understanding mechanisms for new drugs during preclinical studies.

What is non-alcoholic steatohepatitis?

Non-alcoholic steatohepatitis (NASH) is generally characterized by elevated lipid deposition in liver tissue with fibrosis and inflammation, due to various reasons other than excess alcohol intake. NASH is considered as the most severe type of NAFLD. General clinical symptoms may evolve during the progression/exacerbation of NASH, including fatigue, gratuitous weight loss, weakness, an ache in the belly.

Non-Alcoholic Steatohepatitis (NASH) Model

It is still not clear why some people with fatty liver get NASH while others don't. It is speculated that inflammatory responses may play a key role. Genetic factors may also be involved in susceptivity and development of NASH. Commonly recognized risk factors of NASH may include:

  • Obesity
  • Metabolic syndrome
  • Type II diabetes
  • High cholesterol and high triglycerides

The advantages of non-human primates (NHPs) models

Non-human primates (NHPs) are widely used animal models to characterize disease progression and therapeutics of human being. Human and non-human primates (NHPs) are very similar in size, behavior, physiology, biochemistry, structure, and function of organs, and many other aspects. NHPs models manifest as a valuable toolbox that bridges translational research from small animal models to humans.

Non-Alcoholic Steatohepatitis (NASH) Model

NASH models provided by Creative Biolabs

Our team provides the super-class DIO + CCl4 induced NASH model. We have developed comprehensive measurements for studying NASH as follows:

  • Body weight, water intake, food intake, defecation
  • Typical diabetic and lipid profiling
  • Liver-specific biochemical function tests
  • Imaging studies (e.g. non-invasive liver-specific ultrasound and magnetic resonance)
  • Percutaneous liver biopsy for determining NASH activity score and fibrosis score
  • Liver weight, spleen weight, ascites measurement, portal vein pressure

Creative Biolabs has successfully established and integrated plenty of NHP models according to diverse custom needs. In addition to liver disease models, we are also expertise in tailoring alternative disease models including neurological disease, renal disease, cardiovascular and metabolic disorders, urogenital disease, immune disease, etc. With abundant knowledge reserves and state-of-the-art technologies, we are committed to delivering the most satisfactory service using the most relevant NHP disease models. Please feel free to contact us for further discussions.

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