Ocular Disease Modeling & Pharmacodynamics Services
Introduction
As a global leader in preclinical ophthalmic research, Creative Biolabs offers numerous ocular disease models for worldwide clients to enable directed and meaningful preclinical drug discovery and development programs. Our experienced experts can help you select the right model and assay with extensive information on each eye disease model. In addition, we can provide custom studies to meet the specific needs of a particular compound or discovery project.
Ocular Disease Models Available at Creative Biolabs
Creative Biolabs can provide numerous rodent research models to enable directed and meaningful preclinical drug discovery and development programs. With extensive experience, we conduct each model coupled with different parameters that can be used to evaluate the efficacy of candidate drugs. Importantly, our professional team which is supported by internal PK/Bioanalytical, ex vivo pharmacology and in vitro biology experts will work closely with you to ensure the most reliable data can be achieved. To learn more details about different ocular disease models, you can click on the links below:
- Scopolamine-Induced Dry Eye Models
- Benzalkonium Chloride-Induced Dry Eye Models
- Low Humidity Environment-Induced Dry Eye Models
- Low Humidity Environment and Cholinergic Receptor Antagonists-Induced Dry Eye Models
- Sleep Deprivation-Induced Mouse Dry Eye Models
- Sodium Selenite-Induced Cataract Models
- UVR-B Induced Cataract Models
- Diabetic Cataract Models
- Congenital Cataract Models
- NMDA-Induced Retinal Ganglion Cells (RGCs) Injury Models
- Optic Nerve Clamp Induced Optic Nerve Injury Models
- Hypertonic Saline Injection Models
- Spontaneous Glaucoma Mouse Models
- Anterior Chamber Injection Model
- Sodium Lodate-Induced Retinal Degeneration Models
- Blue/White Light-Induced Retinal Degeneration Models
- MNU-Induced Retinal Degeneration Models
- Laser-Induced Choroidal Neovascularization (CNV) Models
- DL-AAA-Induced Retinal Neovascularization and Leakage Models
- VEGF-Induced Retinal Leakage Models
- Spontaneous CNV Model (Jr5558 Mice)
- HUVEC Tube Formation assay
- Hyperoxia-Induced Retinal Neovascularization Models
- Hypertension-Induced Retinal Ischemia-Reperfusion Injury Models
- Streptozotocin-Induced Diabetic Retinopathy Models
- Streptozotocin-Induced Diabetic Cataract Models
- Diabetic Macular Edema Models
- Two-Stage Laser-Induced Subretinal Fibrosis Secondary to CNV
- Proliferative Vitreoretinopathy (PVR) Models
- Laser-Induced Retinal Vein Occlusion (RVO) Models
- Experimental Autoimmune Uveitis (EAU) Models
- LPS-Induced Uveitis Models
- Graves' Ophthalmopathy Models
- Allergic Conjunctivitis Models
- Bacterial Conjunctivitis Models
- Infectious Keratitis Models
- Capsaicin-Induced Corneal Neuritis Models
Fig.1 From gene discovery to therapy of retinal degenerative diseases.1
Our Capabilities
At Creative Biolabs, we understand that innovative ocular disease model development is essential for your drug's success. With meticulous research and objective interpretation of data, our experienced Ph.D. and M.D. study directors perform standard guidelines and work closely with Creative Biolabs's other preclinical development multidisciplinary teams to advance your compound and device innovations.
- Animals: Mouse, Rat, Rabbit, NHPs
- Route of administration: Eye drops, anterior chamber injection, intravitreal injection, subretinal injection, suprachoroidal injection, retrobulbar injection
- Eye tissue sampling: cornea, conjunctiva, iris, lens, retina, choroid, optic nerve, aqueous humor, vitreous, whole blood, plasma, serum, tears
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Ophthalmological examination
- Slit lamp examination
- Direct/indirect ophthalmoscopy
- Fundus photography (FP)
- Optical coherence tomography (OCT)
- Fundus fluorescein angiography (FFA)
- Fundus infrared/autofluorescence imaging
- Intraocular pressure test
- Semi-quantitative preclinical ocular toxicity score (SPOTS)
- Laser photocoagulation
- Flash visual evoked potential (f-VEP)
- Flash electroretinogram (f-ERG)
- Corneal injury fluorescence test
- Corneal sensitivity test
- Optomotor response test (OMR)
- Draize test
Creative Biolabs is happy to share our top-notch technology and abundant experience with global customers. Before the initial start of model creation, we will conduct stringent pre-screening ophthalmic exams to eliminate pre-existing ocular defects that could adversely affect the outcome of your ocular studies. If you are interested in the service we can provide, please feel free to contact us or send us an inquiry.
Reference
- Veleri S, et al. Biology and therapy of inherited retinal degenerative disease: insights from mouse models. Disease models & mechanisms, 2015, 8(2): 109-129.
For Research Use Only.