CyLip-20, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ177)
CyLip-20 is a cyclic lipopeptide antimicrobial peptide that targets Gram-positive and Gram-negative bacteria. CyLip-20 exhibits low hemolytic activity and mild in vivo toxicity. CyLip-20 disrupts the integrity of bacterial outer membrane, inner membrane and cytoplasmic membrane by binding to bacterial lipopolysaccharide (LPS), triggering membrane permeabilization, depolarization and leakage of intracellular contents, and inhibits bacterial biofilm formation. In animal models, CyLip-20 reduces the bacterial load in skin wounds of mice infected with MRSA, promotes wound healing, decreases the levels of inflammatory cytokines and reduces inflammatory cell infiltration. CyLip-20 can be used in research related to MRSA skin wound infections.
| Overview | |
|---|---|
| Synonyms | CyLip-20; CyLip20; Cysteine-rich lipopeptide 20 |
| Source | Synthetic |
| Sequence | C8-{Dab}-{Dab}-Trp-{d-Tyr}-cyclo(Lys-{Dab}-{Dab}-Trp-{d-Leu}-{d-Leu}-Glu) |
| Sequence Shortening | C8-{Dab}-{Dab}-W-{d-Tyr}-cyclo(K-{Dab}-{Dab}-W-{d-Leu}-{d-Leu}-E) |
| Activity | Gram-positive bacteria; Gram-negative bacteria; Fungi; Virus; Cancer cells; Biofilm |
| Physical State | Powder |
| Purity | >98% |
| Storage | The power can be stored at 4°C for 2 years or at -20°C for 3 years. |
For Research Use Only.
- P9R, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ545)
- Bombinin H2, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ294)
- Epinecidin-1, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ399)
- CRAMP, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ59)
- HPA3NT3-A2, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ438)
- Pantinin-2, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ549)
- Retrocyclin-101, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ105)
- Cecropin P1, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ47)