Gy-CATH, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ425)
Gy-CATH is an anionic antimicrobial peptide. Gy-CATH activates MAPK and NF-κB signaling pathways (elevated levels of phospho-ERK, -p38, -JNK, -p65, and -IκBα). Gy-CATH upregulates the expression levels of three physiological anticoagulant pathways. Gy-CATH inhibits ADP-, Collagen-, and PMA-induced platelet aggregation. Gy-CATH has no direct antimicrobial activity, but shows significant preventive abilities against mice infected with Staphylococcus aureus, Escherichia coli, and Methicillin (HY-121544)-resistant Staphylococcus aureus. Gy-CATH exhibits potent immunomodulatory activity, enhancing macrophage-and neutrophil-mediated bactericidal functions. Gy-CATH significantly reduces the extent of pulmonary fibrin deposition and prevents thrombosis in mice.
| Overview | |
|---|---|
| Synonyms | Gy-CATH; Gymnura cathelicidin |
| Source | Snake/Reptile |
| Sequence | Ala-Glu-Glu-Glu-Ala-Glu-Lys-Thr-His-Lys-Thr-Glu-Cys-Leu-Glu-Cys-Ile-Phe-Thr-Leu-Le u-Pro-Pro-Ala (Disulfide bridge: Cys13-Cys16) |
| Sequence Shortening | AEEEAEKTHKTECLECIFTLLPPA (Disulfide bridge: Cys13-Cys16) |
| Activity | Gram-positive bacteria; Gram-negative bacteria; Fungi; Virus; HIV; Cancer; Biofilm; LPS; Snake; Gloydius ussuriensis |
| Physical State | Powder |
| Purity | >98% |
| Storage | The power can be stored at 4°C for 2 years or at -20°C for 3 years. |
For Research Use Only.
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