HVF18-a3-d, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ445)
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HVF18-a3-d is an antimicrobial peptide. HVF18-a3-d reduces NO production. HVF18-a3-d inhibits the production of TNF-α and IL-6, reduces ROS production, and suppresses the TLR4 signaling pathway, as well as LPS-induced phosphorylation of ERK, JNK, and p38 MAPK. HVF18-a3-d exhibits antimicrobial activity against a variety of bacteria by disrupting their outer and inner membranes. HVF18-a3-d protects mice from fatal septic shock induced by Acinetobacter baumannii resistant to Carbapenem. HVF18-a3-d shows anti-inflammatory and antioxidant effects.
| Overview | |
|---|---|
| Synonyms | HVF18-a3-d; HVF18a3d |
| Source | Synthetic |
| Sequence | d-{Gly-Val-Phe-Arg-Leu-Lys-Lys-Trp-Leu-Lys-Lys-Val-Leu-Lys-Lys-Trp-Gly-Lys}-NH2 |
| Sequence Shortening | d-{GVFRLKKWLKKVLKKWGK}-NH2 |
| Activity | Gram-positive bacteria; Gram-negative bacteria; Fungi; Virus; Cancer cells; Biofilm |
| Physical State | Powder |
| Purity | >98% |
| Storage | The power can be stored at 4°C for 2 years or at -20°C for 3 years. |
For Research Use Only.
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